{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:58:11Z","timestamp":1789243091538,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005706","name":"Beijing Technology and Business University","doi-asserted-by":"publisher","award":["20181045"],"award-info":[{"award-number":["20181045"]}],"id":[{"id":"10.13039\/501100005706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630023"],"award-info":[{"award-number":["81630023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400444"],"award-info":[{"award-number":["81400444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108009"],"award-info":[{"award-number":["81420108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570895"],"award-info":[{"award-number":["81570895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>It is not unequivocally proven whether a combination of an intranasal corticosteroids (INSs) and a cysteinyl leukotriene receptor antagonist has greater efficacy than INSs in the treatment of seasonal allergic rhinitis (SAR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single\u2010center, randomized, open\u2010label study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study subjects included 46 participants with SAR. Participants were randomized to receive budesonide (BD; 256 \u03bcg) plus montelukast (MNT; 10 mg) (BD\u2009+\u2009MNT) or BD alone (256 \u03bcg) for 2\u2009weeks. Visual analog scale scores for five major symptoms of SAR, nasal cavity volume (NCV), nasal airway resistance (NAR), and fractional exhaled nitric oxide (FeNO) were assessed before and at the end of treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatments significantly improved the five main SAR symptoms from baseline; however, BD\u2009+\u2009MNT produced significantly greater improvements in nasal blockage and nasal itching compared to BD alone. At baseline, the nasal blockage score was significantly correlated with NCV and NAR (<jats:italic>r<\/jats:italic> =\u2009\u22120.473, <jats:italic>P<\/jats:italic> =\u2009.002 and <jats:italic>r<\/jats:italic> =\u2009\u22120.383, <jats:italic>P<\/jats:italic> =\u2009.013, respectively). After 2\u2009weeks of treatment, BD\u2009+\u2009MNT significantly improved NCV, but not NAR, to a greater level than BD. The number of patients with FeNO concentration\u2009\u2265\u200930 ppb at baseline was significantly decreased after BD\u2009+\u2009MNT treatment, but not after BD treatment. Similarly, BD\u2009+\u2009MNT treatment led to a significantly greater decrease in FeNO concentration than BD treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BD\u2009+\u2009MNT treatment may have an overall superior efficacy than BD monotherapy for patients with SAR, especially in improvement of nasal blockage, itching, and subclinical lower airway inflammation. Also, NCV and NAR could be used to assess nasal blockage more accurately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b <jats:italic>Laryngoscope<\/jats:italic>, 131:E1054\u2013E1061, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28433","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T14:51:56Z","timestamp":1575039116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Randomized Trial of Comparing a Combination of Montelukast and Budesonide With Budesonide in Allergic Rhinitis"],"prefix":"10.1002","volume":"131","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery"},{"name":"and Department of Allergy Beijing TongRen Hospital, Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of 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