{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:06:02Z","timestamp":1773043562178,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Advanced nasal malignancies may require rhinectomy, which can have profound psychosocial impacts. Rhinectomy defects can be rehabilitated through surgery or prosthetics. We seek to understand the health utility of the rhinectomy defect, surgical, and prosthetic reconstruction, which have not been previously studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective clinical study<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult na\u00efve observers (n = 273) ranked the utility of five randomized health states (monocular blindness, binocular blindness, post\u2010rhinectomy nasal defect, postsurgical reconstruction, and post\u2010prosthetic rehabilitation). Health utilities were measured using visual analogue scale (VAS), standard gamble (SG), and time trade\u2010off (TTO). One\u2010way analysis of variance (ANOVA) with post hoc Scheffe's test and the independent samples T\u2010test for a priori comparisons were performed. Multiple linear regression was performed using participant demographics as independent predictors of utility scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Health utilities (VAS, SG, TTO) were reported as follows (mean\u2009\u00b1\u2009SD): monocular blindness (0.71\u2009\u00b1\u20090.21, 0.84\u2009\u00b1\u20090.20, 0.85\u2009\u00b1\u20090.19), binocular blindness (0.48\u2009\u00b1\u20090.25, 0.68\u2009\u00b1\u20090.28, 0.63\u2009\u00b1\u20090.28), post\u2010rhinectomy nasal defect (0.59\u2009\u00b1\u20090.24, 0.74\u2009\u00b1\u20090.24, 0.74\u2009\u00b1\u20090.24), postsurgical reconstruction (0.88\u2009\u00b1\u20090.16, 0.90\u2009\u00b1\u20090.18, 0.89\u2009\u00b1\u20090.13), and post\u2010prosthetic rehabilitation (0.67\u2009\u00b1\u20090.22, 0.80\u2009\u00b1\u20090.23, 0.82\u2009\u00b1\u20090.20). Both surgical reconstruction (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and prosthetic rehabilitation (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) significantly improved health utility. SG and TTO utility scores were inversely associated with observer age (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and participants who identified themselves as non\u2010Caucasians (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) in post\u2010rhinectomy nasal defect, post\u2010nasal surgical reconstruction, and post\u2010nasal prosthetic rehabilitation health states, while higher levels of education were directly associated with SG scores (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to demonstrate the significant negative impact of the rhinectomy nasal defect on health utility. Rehabilitation by surgical or prosthetic techniques significantly increases health utility as rated by na\u00efve observers. <jats:italic>Laryngoscope<\/jats:italic>, 130:1674\u20131679, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28480","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T15:39:34Z","timestamp":1576597174000},"page":"1674-1679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Health utility of rhinectomy, surgical nasal reconstruction, and prosthetic rehabilitation"],"prefix":"10.1002","volume":"130","author":[{"given":"Callum","family":"Faris","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Antwerp Medical Center  Antwerp Belgium U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Heiser","sequence":"additional","affiliation":[{"name":"Division of Facial Plastic and Reconstructive Surgery Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Quatela","sequence":"additional","affiliation":[{"name":"Division of Facial Plastic and Reconstructive Surgery Massachusetts Eye and Ear Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head &amp; 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