{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:11:49Z","timestamp":1788304309856,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013211","name":"IRIS","doi-asserted-by":"publisher","award":["2019"],"award-info":[{"award-number":["2019"]}],"id":[{"id":"10.13039\/100013211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical features and the therapeutic response of laryngopharyngeal reflux (LPR) patients with or without gastroesophageal reflux disease (GERD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with LPR symptoms were enrolled from three European Hospitals. The diagnosis of LPR and GERD was made through impedance\u2010pH monitoring (MII\u2010pH). A gastrointestinal endoscopy was realized in patients with digestive complaints or\u2009\u226560\u2009years old. The 3\u2010 to 6\u2010month treatment was based on the association of diet, pantoprazole, alginate, and magaldrate regarding the MII\u2010pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used to evaluate the clinical evolution throughout treatment. The gastrointestinal endoscopy findings, clinical features, and therapeutic response were compared between patients with LPR and GERD (LPR\/GERD) and patients with LPR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and eleven LPR patients were included, 54 being LPR\/GERD. LPR\/GERD patients had a higher number of proximal reflux episodes compared with LPR patients. The prevalence of esophagitis, hernia hiatal, and lower esophageal sphincter insufficiency did not differ between groups. The presence of GERD was strongly associated with acid LPR. Patients without GERD had a higher proportion of nonacid and mixed LPR compared with LPR\/GERD patients. The pre\u2010 to posttreatment evolutions of RSS and RSA were quite similar in both groups, with the exception of the 3\u2010 to 6\u2010month improvement of digestive symptoms, which was better in LPR\/GERD group. The therapeutic success rates were 79.6% and 77.2% in GERD\/LPR and LPR group, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GERD is predictive of acid LPR. The clinical evolution and the therapeutic response rates were quite similar in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        4\n                        <jats:italic>Laryngoscope<\/jats:italic>\n                        , 130: E479\u2013E489, 2020\n                      <\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.28482","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T05:15:39Z","timestamp":1577337339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Gastroesophageal reflux in laryngopharyngeal reflux patients: Clinical features and therapeutic response"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)"},{"name":"Laboratory of Anatomy and Cell Biology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Bruxelles, CHU Saint\u2010Pierre, School of Medicine"},{"name":"Department of Head and Neck Surgery Centre Oscar Lambret  Lille"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, Foch Hospital University of Paris Saclay  Poitiers 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Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Horoi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Bruxelles, CHU Saint\u2010Pierre, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Thill","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Bruxelles, CHU Saint\u2010Pierre, School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery CHU de Bruxelles, CHU Saint\u2010Pierre, 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