{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:04:17Z","timestamp":1791389057732,"version":"4.3.3"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008388","name":"Radiumhospitalets Forskningsstifltelse","doi-asserted-by":"publisher","award":["335007 \u2010 19"],"award-info":[{"award-number":["335007 \u2010 19"]}],"id":[{"id":"10.13039\/501100008388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cisplatin\u2010related hearing loss (HL) is claimed to progress after treatment. This controlled longitudinal study with extended follow\u2010up investigates HL in testicular cancer survivors (TCSs) after cisplatin\u2010based chemotherapy (CBCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Controlled longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010two TCSs treated with CBCT between 1980 and 1994 in Norway participated in two surveys (S1\/S3), including pure\u2010tone audiograms (0.125\u20138 kHz) and self\u2010reported HL, 12 and 31\u2009years after treatment, respectively. Hearing thresholds were age\u2010adjusted based on age\u2010matched hearing thresholds from the general population (controls). Hearing loss was defined as thresholds &gt;20 dB at any frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between the two surveys, the prevalence of high\u2010frequency HL (4, 6, and 8 kHz) increased from 73% to 94% but approached those of the aging general population after age adjustment. In TCSs aged &gt;40\u2009years at first survey, HL at the subsequent survey equaled that of controls. Self\u2010reported HL increased from seven (9%) at S1 to 20 (26%) at S3. At S1, age\u2010adjusted HL was identified in all (seven) TCSs reporting decreased hearing whereas at S3, hearing thresholds did not differ from controls in seven out of 20 patients reporting HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CBCT\u2010related ototoxicity causes high\u2010frequency HL, but in contrast to reports from follow\u2010up studies from the first post\u2010treatment decade, no major progression was found beyond the first post\u2010treatment decade for frequencies 0.125\u20138 kHz. Importantly, with extended follow\u2010up, hearing thresholds of patients approach those of the general population, possibly due to a less\u2010than\u2010additive effect with age\u2010related hearing loss (ARHL) in CBCT\u2010treated patients. Age\u2010and sex\u2010matching is strongly advised in long\u2010term follow\u2010up of CBCT\u2010related ototoxicity. Specificity for detecting ototoxicity with self\u2010reported questionnaires decreases with extended follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 130:E515\u2013E523, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28543","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:38:41Z","timestamp":1581939521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Relationship Between Cisplatin\u2010related and Age\u2010related Hearing Loss During an Extended Follow\u2010up"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-8072","authenticated-orcid":false,"given":"Jakob","family":"Skalleberg","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Oslo University Hospital, Rikshospitalet  Oslo 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