{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:22Z","timestamp":1791946102000,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of the various therapies used for the prevention of vestibular migraine (VM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Primary studies were identified though PubMed, Scopus, PsycINFO, and Cochrane Library by two independent investigators for articles published through April 2019. The search identified randomized comparison or observational studies pertaining to vestibular migraine treatment. Meta\u2010analysis was performed on pre\u2010 and posttreatment Dizziness Handicap Inventory, vertigo frequency, and percentage of perceived improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Literature search identified 13 studies that reported sufficient outcome measures to be included in the analysis. Patients with VM had a mean age of 43.3\u2009years with female\u2010to\u2010male gender ratio of 2.1:1. Classes of therapeutic agents included antiepileptic drugs, calcium channel blockers, tricyclic antidepressants, \u03b2\u2010blockers, serotonin and norepinephrine reuptake inhibitors, and vestibular rehabilitation. All treatment options that were analyzed demonstrated improvement in all of the outcome parameters, but due to significant heterogeneity and lack of standardized reporting on outcomes, establishment of preferred treatment modality could not be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Various treatment modalities have been evaluated for preventative treatment of VM. Physician familiarity, patient comorbidities, and the side\u2010effect profiles of various interventions likely influence the selection of intervention. Future randomized controlled trials with restrictive inclusion criteria and generalizable standardized outcome measures will allow for more robust meta\u2010analyses and for more evidence\u2010based treatment of vestibular migraines. <jats:italic>Laryngoscope<\/jats:italic>, 131:186\u2013194, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28546","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:26:17Z","timestamp":1582295177000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Treatment of Vestibular Migraine: A Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2485-4089","authenticated-orcid":false,"given":"Young Jae","family":"Byun","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina"},{"name":"Department of Medicine, University of Central Florida College of Medicine  Orlando Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan A.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina"},{"name":"Department of Medicine, Quinnipiac University Frank H. 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