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The most common diagnosis in adult\u2010onset HL is presbycusis. However, the age of onset of presbycusis varies, and patients often describe family history of HL as well as individual variation in progression and severity. In recent years, there has been accumulating evidence of gene\u2013environment interactions underlying adult cases of HL. Susceptibility loci for age\u2010related HL have been identified, and genes related to postlingual nonsyndromic HL continue to be discovered through individual reports and genome\u2010wide association studies. This review will outline main concepts in genetics as related to HL, identify implicated genes, and discuss clinical implications. <jats:italic>Laryngoscope<\/jats:italic>, 131:401\u2013409, 2021<\/jats:p>","DOI":"10.1002\/lary.28646","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T16:24:07Z","timestamp":1585931047000},"page":"401-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genetics of Postlingual Sensorineural Hearing Loss"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-5387","authenticated-orcid":false,"given":"Shadi","family":"Ahmadmehrabi","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine, Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Genetics Perelman School of Medicine, University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-0679","authenticated-orcid":false,"given":"Jason","family":"Brant","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Perelman School of Medicine, University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Genetics Perelman School of Medicine, University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ruckenstein","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Perelman School of Medicine, University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Rader","sequence":"additional","affiliation":[{"name":"Department of Genetics Perelman School of Medicine, University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"The National Institute on Deafness and Other Communication Disorders (NIDCD) the National Institutes of Health (NIH). 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