{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:13Z","timestamp":1759335853467,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>In this study, we retrospectively reviewed medical records of patients who underwent surgery for p16+ oropharyngeal cancer and analyzed the prognostic implications of pathologic lymph node (LN) status, including number of metastatic LNs, LN ratio, and location of metastatic LNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data on patients diagnosed with p16+ oropharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population consisted of 159 males and 29 females with a mean age of 57.2\u2009years. The primary tumor sites were tonsils (n = 160), base of the tongue (n = 24), and soft palate (n = 4). Only recurrence\u2010free survival (RFS) showed a significant correlation with contralateral LN metastasis on multivariate analysis. On Kaplan\u2010Meier analysis, 5\u2010year RFS was 92.4% in patients without contralateral LN metastasis and 68.8% in patients with contralateral LN metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among pathologic LN status in p16+ oropharyngeal cancer, only contralateral LN metastasis showed prognostic significance in disease recurrence of p16+ oropharyngeal squamous cell carcinoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p><jats:bold>4 <jats:italic>Laryngoscope<\/jats:italic>, 130: 1973\u20131979, 2020<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28665","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T14:54:15Z","timestamp":1586789655000},"page":"1973-1979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Significance of Lymph Node Status in p16+ Oropharyngeal Cancer 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-5859","authenticated-orcid":false,"given":"Se\u2010Heon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Chang","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine  Seoul South 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