{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:51:10Z","timestamp":1789833070836,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AAFPRS Research Scholar Award","award":["630048"],"award-info":[{"award-number":["630048"]}]},{"name":"Douglas and Diana Berthiaume Family","award":["Donation to Surgical Photonics & Engineering Labor"],"award-info":[{"award-number":["Donation to Surgical Photonics & Engineering Labor"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Contemporary clinical assessment of vocal fold adduction and abduction is qualitative and subjective. Herein is described a novel computer vision tool for automated quantitative tracking of vocal fold motion from videolaryngoscopy. The potential of this software as a diagnostic aid in unilateral vocal fold paralysis is demonstrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A deep\u2010learning algorithm was trained for vocal fold localization from videoendoscopy for automated frame\u2010wise estimation of glottic opening angles. Algorithm accuracy was compared against manual expert markings. Maximum glottic opening angles between adults with normal movements (N = 20) and those with unilateral vocal fold paralysis (N = 20) were characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Algorithm angle estimations demonstrated a correlation coefficient of 0.97 (<jats:italic>P<\/jats:italic> &lt;\u2009.001) and mean absolute difference of 3.72\u00b0 (standard deviation [SD], 3.49\u00b0) in comparison to manual expert markings. In comparison to those with normal movements, patients with unilateral vocal fold paralysis demonstrated significantly lower maximal glottic opening angles (mean 68.75\u00b0\u2009\u00b1\u200911.82\u00b0 vs. 49.44\u00b0\u2009\u00b1\u200910.42\u00b0; difference, 19.31\u00b0; 95% confidence interval [CI] [12.17\u00b0\u201326.44\u00b0]; <jats:italic>P<\/jats:italic> &lt;\u2009.001). Maximum opening angle less than 58.65\u00b0 predicted unilateral vocal fold paralysis with a sensitivity of 0.85 and specificity of 0.85, with an area under the receiver operating characteristic curve of 0.888 (95% CI [0.784\u20130.991]; <jats:italic>P<\/jats:italic> &lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A user\u2010friendly software tool for automated quantification of vocal fold movements from previously recorded videolaryngoscopy examinations is presented, termed <jats:italic>automated glottic action tracking by artificial intelligence (AGATI)<\/jats:italic>. This tool may prove useful for diagnosis and outcomes tracking of vocal fold movement disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>IV <jats:italic>Laryngoscope<\/jats:italic>, 131:E219\u2013E225, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28669","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T13:29:26Z","timestamp":1588339766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["An <scp>Open\u2010Source<\/scp> Computer Vision Tool for Automated Vocal Fold Tracking From Videoendoscopy"],"prefix":"10.1002","volume":"131","author":[{"given":"Nat","family":"Adamian","sequence":"first","affiliation":[{"name":"Surgical Photonics &amp; Engineering Laboratory, Department of Otolaryngology \u2013 Head and Neck Surgery Massachusetts Eye and Ear and Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-3984","authenticated-orcid":false,"given":"Matthew R.","family":"Naunheim","sequence":"additional","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology \u2013 Head and Neck Surgery Massachusetts Eye and Ear and Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-0264","authenticated-orcid":false,"given":"Nate","family":"Jowett","sequence":"additional","affiliation":[{"name":"Surgical Photonics &amp; Engineering Laboratory, Department of Otolaryngology \u2013 Head and Neck Surgery Massachusetts Eye and Ear and Harvard Medical School  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3663-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27434"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2006.05.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263230"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2008\/08-0017)"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811701210"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199504000-00005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.11.040"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150701.46377.df"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100105"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.3.8087344"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24812"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.11.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1109\/ISSPA.2007.4555453"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR-S-18-0405"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05728-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26860"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070986"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2016.2637004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2018.0030"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0176-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0209-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.10.011"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.126918"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2007.04.003"},{"key":"e_1_2_7_31_1","volume-title":"Version 1.1.0.0. World Wide Web","author":"Vries J","year":"2012"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2018.2867636"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.05.010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4428-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26930"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.6.2246"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418803961"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700602"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.28669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28669","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:11:25Z","timestamp":1693581085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/lary.28669"],"URL":"https:\/\/doi.org\/10.1002\/lary.28669","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"2019-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}