{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:57:59Z","timestamp":1787497079683,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>For early\u2010stage oral tongue carcinoma and carcinoma in situ (ESOTCCIS), we evaluated patient\u2010reported quality\u2010of\u2010life (QOL) outcomes following resection with primary closure (R\u2010PC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective review at an academic cancer center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010nine ESOTCCIS patients (Tis, T1, T2) who underwent R\u2010PC without radiation completed the University of Washington Quality of Life Questionnaire Version 4 (UW\u2010QOL) at least 6\u2009months since R\u2010PC (mean = 2.39\u2009years; range = 0.5\u20136.7\u2009years). We compared UW\u2010QOL scores for pain, swallowing, chewing, speech, and taste to established normative population scores. Multivariable regression analysis evaluated factors associated with QOL impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ESOTCCIS patients who underwent R\u2010PC in comparison to the normative population reported significantly worse mean speech (87.7 vs. 98,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and taste (85.6 vs. 95,\n                      <jats:italic>P<\/jats:italic>\n                      = .002) scores and no significant differences in mean pain (91.7 vs. 86,\n                      <jats:italic>P<\/jats:italic>\n                      = .96), swallowing (100 vs. 98,\n                      <jats:italic>P<\/jats:italic>\n                      = .98), chewing (97.4 vs. 94,\n                      <jats:italic>P<\/jats:italic>\n                      = .98) scores. For speech and taste, 59% (23\/39) reported no postoperative change from baseline, whereas 41% (16\/39) and 35.9% (14\/39) reported mild impairment, respectively. Overall, postoperative QOL was reported as good, very good, or outstanding by 87.2% (34\/39). Higher American Society of Anesthesiologists class, cT1 compared to CIS, and ventral tongue involvement were independently associated with worse speech. Age\u2009&lt;\u200960\u2009years was independently associated with worse taste.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ESOTCCIS patients who undergo R\u2010PC without radiation can expect long\u2010term swallowing, chewing, and pain to be in the normative range. Although a majority of patients can expect to achieve normative speech and taste outcomes, R\u2010PC carries the risks of mild speech and\/or taste impairments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 131:312\u2013318, 2021\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.28723","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T08:43:13Z","timestamp":1588840993000},"page":"312-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Patient\u2010Reported Quality of Life After Resection With Primary Closure for Oral Tongue Carcinoma"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-5493","authenticated-orcid":false,"given":"Edgar","family":"Ochoa","sequence":"first","affiliation":[{"name":"School of Medicine University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-5801","authenticated-orcid":false,"given":"Andrew R.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-0913","authenticated-orcid":false,"given":"Mary","family":"Han","sequence":"additional","affiliation":[{"name":"School of Medicine University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Webb","sequence":"additional","affiliation":[{"name":"Albany Medical College  Albany New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-8000","authenticated-orcid":false,"given":"Gaelen B.","family":"Stanford\u2010Moore","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan H.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"George","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick K.","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase M.","family":"Heaton","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery University of California  San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(98)90061-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880150207"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.38"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2009.04.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199710000-00005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.069"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4683-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1206-2"},{"key":"e_1_2_6_10_1","unstructured":"LoweD RogersS. 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