{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:07:34Z","timestamp":1789132054313,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IRIS Recherche","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To investigate the profile of patients with laryngopharyngeal reflux (LPR) at hypopharyngeal\u2013esophageal multichannel intraluminal impedance\u2010pH (HEMII\u2010pH) monitoring and the relationship between hypopharyngeal\u2010proximal reflux episodes (HREs) and saliva pepsin concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective non\u2010controlled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were recruited from three European hospitals from January 2018 to October 2019. Patients benefited from HEMII\u2010pH monitoring and saliva collections to measure saliva pepsin concentration in the same time. Saliva pepsin concentration was measured in the morning (fasting), after lunch, and after dinner. The LPR profile of patients was studied through a breakdown of the HEMII\u2010pH findings over the 24 hours of testing. The relationship between the concentrations of saliva pepsin and 24\u2010hour HREs was studied through linear multiple regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred twenty\u2010six patients completed the study. The HEMII\u2010pH analyses revealed that 73.99% of HREs occurred outside 1\u2010hour postmeal times, whereas 20.49% and 5.52% of HREs occurred during the 1\u2010hour postmeal and nighttime, respectively. Seventy\u2010four patients (58.73%) did not have nighttime HREs. Patients with both daytime and nighttime HREs had more severe HEMII\u2010pH parameters and reflux symptom score compared with patients with only daytime HREs. There were no significant associations between HREs and saliva pepsin concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Unlike gastroesophageal reflux disease, HREs occur less frequently after meals and nighttime. The analysis of the HEMII\u2010pH profile of the LPR patients has to be considered to develop future personalized therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 131:268\u2013276, 2021\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.28736","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T18:41:55Z","timestamp":1590086515000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["<scp>Hypopharyngeal\u2010Esophageal Impedance\u2010pH<\/scp>\n                    Monitoring Profiles of Laryngopharyngeal Reflux Patients"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine University of Mons Research Institute for Health Sciences and Technology, University of Mons  Mons Belgium"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine Training and Research Unit, Simone Veil, University of Versailles Saint\u2010Quentin\u2010en\u2010Yvelines (University of Paris\u2013Saclay)  Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Bobin","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Otolaryngology Polyclinic of Poitiers\u2013Elsan  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Dapri","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine University of Mons Research Institute for Health Sciences and Technology, University of Mons  Mons Belgium"},{"name":"European Laparoscopic School, School of Medicine Free University of Brussels  Brussels Belgium"},{"name":"International School Reduced Scar Laparoscopy  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Eisendrath","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Gastroenterology and Endoscopy University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charelle","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Mouawad","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Centers Lille, Hospital Claude Huriez, School of Medicine, University of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Horoi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Thill","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris France"},{"name":"Department of Gastroenterology and Endoscopy University Hospital Centers Brussels, University Hospital Centers Saint\u2010Pierre, School of Medicine, Free University of Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Saussez","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies  Paris 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Pepsin concentration in saliva of laryngopharyngeal reflux patients is influenced by meals consumed before the samples. [Accepted for publication in Laryngoscope 2020.] Abstract presented at: American Laryngological Association Meeting at the Combined Otolaryngology Spring Meetings; April 22\u201324 2020; Atlanta GA."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001066"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12358"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.28736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T04:02:23Z","timestamp":1693627343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/lary.28736"],"URL":"https:\/\/doi.org\/10.1002\/lary.28736","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"assertion":[{"value":"2020-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}