{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:34:50Z","timestamp":1789220090827,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well\u2010characterized cohort of patients with primary or secondary Sj\u00f6gren's syndrome (SS) meeting the American\u2013European Consensus Group criteria.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Retrospective, observational, monocentric study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six patients (81% female, mean age = 48\u2009\u00b1\u200935\u2009years) with primary or secondary SS who underwent MRSIAL were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MRSIAL revealed characteristic radiological signs in the parotid, sublingual, and submandibular salivary glands in 35\/36 patients (97%). Patients presenting with anti\u2010Sj\u00f6gren's syndrome\u2013related antigen A (SSA) autoantibodies showed more often fatty infiltration, a \u201cpepper\u2010and\u2010salt\u201d appearance, ductal stenosis, and\/or ductal dilation of the parotid gland (88%, 88%, and 72% respectively) than patients negative for anti\u2010SSA (12%, 4%, and 28% respectively). MRSIAL demonstrated signs characteristic of SS in all 11 patients with negative minor salivary gland biopsy. For 15 patients undergoing ultrasound examination only, 11 (73%) had SS findings, but all 15 had SS findings on MRSIAL. Two cases of parotid lymphoma were detected by MRSIAL (6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MRSIAL is a reliable technique to detect glandular anomalies in patients with SS, and seems to provide a valuable aid in the diagnosis of SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E83\u2013E89, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28742","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T07:01:55Z","timestamp":1589612515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-988X","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Department of Dermatology Geneva University Hospitals  Geneva Switzerland"},{"name":"Department of Allergology and Clinical Immunology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Radiology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Geneva University Hospitals  Geneva 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