{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:50:08Z","timestamp":1790704208678,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671005"],"award-info":[{"award-number":["81671005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974151"],"award-info":[{"award-number":["81974151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the clinical, laboratory, radiological, histopathological, and immunohistochemical features, and the expression of allergy\u2010related cytokines in eosinophilic sialodochitis (ES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight patients diagnosed with chronic obstructive sialadenitis (COS) who had undergone glandular excision or incisional biopsy were enrolled. Seventeen patients with comorbid atopic disease and increased ductal tissue eosinophils comprised the ES group, while 21 patients comprised the COS group. The clinicopathological features and allergy\u2010related cytokine expression were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ES group frequently involved multiple, bilateral major salivary glands, and the number of glands was significantly greater than the COS group (2.8\u2009\u00b1\u20091.1 vs. 1.2\u2009\u00b1\u20090.4, <jats:italic>P<\/jats:italic> &lt;\u2009.001). Serum immunoglobulin (Ig) E was elevated in 91% of patients in ES group (419\u2009\u00b1\u2009357 kU\/L) and peripheral blood eosinophil was significantly greater compared with the COS group (7.6%\u2009\u00b1\u20094.6% vs. 2.5%\u2009\u00b1\u20091.4%, <jats:italic>P<\/jats:italic> &lt;\u2009.001). Histologically, eosinophil infiltration in ES group was observed around the main and interlobular ducts (50\u2009\u00b1\u200939\/high power field [HPF]). Follicular hyperplasia (76%), epithelial mucous metaplasia (82%), and mucus plugs with eosinophils (41%) were observed. IgE\u2010positive cell count was 20.7\u2009\u00b1\u200918.3\/HPF and tryptase\u2010positive mast cell count was 23.5\u2009\u00b1\u200915.1\/HPF, which was significantly greater than the respective cell counts in COS group, which mainly infiltrated around the ducts. The levels of interleukin\u20104, interleukin\u201013, and eotaxin in tissue were significantly greater in ES than the COS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinicopathological characteristics of ES are significantly different from COS and ES might have an allergy\u2010related pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E800\u2013E806, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28772","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T12:04:45Z","timestamp":1593864285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Eosinophilic Sialodochitis: A Type of Chronic Obstructive Sialadenitis Related to Allergy"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-3982","authenticated-orcid":false,"given":"Wen\u2010Xuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-0003","authenticated-orcid":false,"given":"Deng\u2010Gao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology  Beijing 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