{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:29:35Z","timestamp":1785713375937,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluated the efficacy and safety of in\u2010office potassium titanyl phosphate (KTP) laser treatment for the management of epistaxis in hereditary hemorrhagic telangiectasia (HHT) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case series of all HHT patients over age of 18 who underwent in\u2010office KTP laser treatment from July 1, 2017 to December 31, 2019 was performed. The primary outcome measure was the epistaxis severity score (ESS) pre\u2010 and post\u2010procedure. Secondary outcome measures included patient reported pain (on a 10\u2010point Likert\u2010type scale), and procedural adverse events and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16 patients underwent KTP in\u2010office laser treatment during the review period. There was both a clinically and statistically significant decrease in the ESS after in\u2010office laser treatment, baseline ESS \u20137.24, SD 1.71, follow up ESS \u20134.92, SD 1.83 (mean difference 2.94, 95% confidence interval, 1.83\u20134.04, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). There were no reported adverse events or complications associated with the procedure. The mean pain score reported was 0.19, SD 0.75. The average blood loss was 10.8\u2009mL, SD 37.3. The majority of patients (62.5%, 10\/16) had no blood loss during the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinically and statistically significant decreases were noted in the ESS of HHT patients after in\u2010office KTP laser photocoagulation. The procedure was well tolerated by patients, without any adverse events or complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E689\u2013E693, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28824","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T18:29:31Z","timestamp":1592504971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>In\u2010Office KTP<\/scp> Laser for Treating Hereditary Hemorrhagic Telangiectasia\u2013Associated Epistaxis"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-6442","authenticated-orcid":false,"given":"Vincent","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head and Neck Surgery, St. Michael's Hospital, Unity Health Toronto University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Kell","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head and Neck Surgery, St. Michael's Hospital, Unity Health Toronto University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E.","family":"Faughnan","sequence":"additional","affiliation":[{"name":"Toronto HHT Centre, Division of Respirology, Department of Medicine, St. Michael's Hospital, Unity Health Toronto University of Toronto  Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rhinology, Department of Otolaryngology\u2013Head and Neck Surgery, St. Michael's Hospital, Unity Health Toronto University of 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