{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:58:11Z","timestamp":1789365491327,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["T32DC000018"],"award-info":[{"award-number":["T32DC000018"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Our primary objective was to compare differences in survival of patients with high\u2010grade salivary gland carcinomas (SGCs) receiving adjuvant neutron versus photon radiotherapy using a hospital\u2010based national cohort and restricted mean survival time (RMST) analysis. Our secondary objective was to compare survival of similar patients treated with primary neutron versus photon radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Multicenter, retrospective population\u2010based study of patients within the National Cancer Database from 2004 to 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One thousand eight hundred forty\u2010four patients were selected on diagnosis of high\u2010grade parotid and submandibular malignancies. One thousand seven hundred seventy\u2010seven patients receiving photon and 67 patients receiving neutron therapy were identified who met inclusion criteria. Patients were then categorized as having primary surgery with adjuvant radiation or primary radiation without prior surgery. Bivariate analysis was performed to assess for differences between groups, and RMST analysis was performed at 1\u2010, 2\u2010, and 5\u2010year timepoints with controlling for available covariate data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in RMST for patients receiving neutrons over photons at 1, 2, and 5\u2009years in the adjuvant setting. Among patients undergoing primary radiotherapy, there was a difference in RMST of 2.29\u2009months at 1 year and 5.05\u2009months at 2\u2009years for neutrons over photons, though this benefit was not observed at 5\u2009years post\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with high grade SGCs undergoing adjuvant photon versus neutron radiotherapy, there was no difference in RMST. There was observed to be a significant difference in RMST at 1 and 2\u2009years among patients undergoing primary neutron therapy of up to 5\u2009months. Given the benefit observed with primary neutron therapy, it should be considered in both the primary and adjuvant treatment setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:541\u2013547, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28830","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T21:06:30Z","timestamp":1593551190000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neutron Therapy for High\u2010Grade Salivary Carcinomas in the Adjuvant and Primary Treatment Setting"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-3946","authenticated-orcid":false,"given":"Harrison","family":"Cash","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Washington Medical Center  Seattle Washington U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4695-6142","authenticated-orcid":false,"given":"R. 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