{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:23:54Z","timestamp":1788067434185,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Chronic rhinosinusitis (CRS), like other sinonasal diseases, may be associated with avoidance of daily activities. Our goal was to identify characteristics associated with avoidance of activities due to CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 194 CRS patients were recruited. CRS symptom burden was assessed with the 22\u2010item Sinonasal Outcome Test (SNOT\u201022). SNOT\u201022 nasal, sleep, ear\/facial discomfort and emotional\/psychological subdomain scores were calculated. Depressed mood was assessed using the two\u2010item Patient Health Questionnaire (PHQ\u20102). Personality traits including conscientiousness, neuroticism, agreeableness, openness, and extraversion were assessed using the Big Five Inventory\u201010 (BFI\u201010) questionnaire. As the primary outcome, participants rated how often in the prior week that they had avoided any activities in day\u2010to\u2010day life due to their nasal or sinus symptoms on a scale of \u201cnever,\u201d \u201crarely,\u201d \u201csometimes,\u201d \u201coften,\u201d or \u201cextremely often.\u201d Ordinal regression models, with bootstrap validation, were used to identify associations between activity avoidance and participants' characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariable analysis, SNOT\u201022 score (odds ratio [OR] = 1.03, 95% CI, 1.01\u20131.04, <jats:italic>P<\/jats:italic> = .026), and conscientiousness personality trait (OR = 1.38, 95% CI, 1.05\u20131.81, <jats:italic>P<\/jats:italic> = .019) were positively associated with activity avoidance while age (OR = 0.98, 95% CI, 0.96\u20130.99, <jats:italic>P<\/jats:italic> = .049) was negatively associated with activity avoidance. Of CRS symptom burden\/SNOT\u201022 subdomains, only the emotional\/psychological subdomain score (OR = 1.28, 95% CI, 1.12\u20131.46, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) was associated with activity avoidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Younger age and the conscientiousness personality trait were associated with activity avoidance in CRS patients. Of CRS\u2010associated symptomatology, sadness and embarrassment were associated with activity avoidance. Emotional traits and personality most strongly predict avoidance of activities in CRS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2c. <jats:italic>Laryngoscope<\/jats:italic>, 131:707\u2013712, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28879","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T18:52:35Z","timestamp":1594061555000},"page":"707-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Emotional and Personality Traits are Determinants of Activity Avoidance in Chronic Rhinosinusitis Patients"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-5111","authenticated-orcid":false,"given":"Madison V.","family":"Epperson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-3508","authenticated-orcid":false,"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene M.","family":"Speth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals\u2010, Nasen\u2010, Ohren\u2010 Krankheiten Hals\u2010und Gesichtschirurgie  Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Caradonna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Division of Otolaryngology Beth Israel Deaconess Medical Center  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens 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