{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:27:29Z","timestamp":1783646849238,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Harry Barberian Scholarship","award":["2018014"],"award-info":[{"award-number":["2018014"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Preliminary investigations suggest that a novel blue light (BL) laser with a wavelength of 445\u2009nm is comparable to the commonly utilized potassium titanyl phosphate (KTP) laser (532\u2009nm) for treatment of various laryngeal pathologies. The objective of the current study is to make a direct histological comparison of the degree of vocal fold scarring after either BL or KTP laser treatment in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>This was a randomized controlled study using rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four Sprague\u2013Dawley rats were randomized to BL or KTP laser treatment. Laser was delivered in non\u2010overlapping pulses to normal rat vocal folds. Larynges in each group were harvested at three time points: post\u2010operative day 1, 30, and 90. Three animals served as negative controls. The excised whole larynges were sectioned transversely and stained with hematoxylin\/eosin and trichrome. Presence of subepithelial inflammation and protein deposition\/fibrosis indicative of scarring were scored semi\u2010quantitatively (from grade 1\u20133) by two pathologists blinded to treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between\u2010group comparison showed that both laser treatments resulted in significantly elevated subepithelial protein deposition\/fibrosis 90\u2009days after treatment compared to negative controls (BL: 2\u2009\u00b1\u20090; KTP: 2.67\u2009\u00b1\u20090.29; control: 1.17\u2009\u00b1\u20090.29; <jats:italic>P<\/jats:italic> &lt;\u2009.05). However, the degree of protein deposition\/fibrosis was significantly higher in the KTP group compared to the BL group (<jats:italic>P<\/jats:italic> =\u2009.016). Within\u2010group comparison showed that the KTP group showed evidence of fibrosis as early as 30\u2009days after treatment, which was not observed in the BL group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study suggests that the degree of scarring is significantly less after BL laser treatment compared to KTP in normal rat vocal fold tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 131:853\u2013858, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28892","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T19:42:51Z","timestamp":1596570171000},"page":"853-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Blue Light Laser Results in Less Vocal Fold Scarring Compared to <scp>KTP<\/scp> Laser in Normal Rat Vocal Folds"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-5868","authenticated-orcid":false,"given":"R. Jun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Laryngology, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Iakovlev","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Streutker","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-2858","authenticated-orcid":false,"given":"Daniel","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Laryngology, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al\u2010Ali","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery Laryngology, Sheikh Khalifa Medical City  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Laryngology, St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500905"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282f1fbb2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500802"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1700481"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/mlg.0b013e31802b5c1c"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2320-9"},{"key":"e_1_2_6_8_1","first-page":"6","volume-title":"A Novel Blue Light Diode Laser (445 nm) for Dental Application","author":"Frentzen M","year":"2016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4974-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400105"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400303"},{"key":"e_1_2_6_13_1","first-page":"3","volume-title":"Vocal Fold Physiology: Contemporary Research and Clinical Issues","author":"Kurita S","year":"1983"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22451"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.119726"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20567"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.07.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12883"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2008.10.011"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24263"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500210"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500406"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225430.42531.c2"},{"key":"e_1_2_6_24_1","first-page":"105","volume-title":"Voice Science","author":"Thibeault SL","year":"2005"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813485099"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.28892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28892","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:48:06Z","timestamp":1693702086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/lary.28892"],"URL":"https:\/\/doi.org\/10.1002\/lary.28892","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]},"assertion":[{"value":"2020-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}