{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:10:21Z","timestamp":1774044621920,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies have evaluated various markers as prognostic predictors in patients with many types of cancers. However, the influence of such factors on the outcomes of patients with parotid gland carcinoma (PGC) is unknown. This study investigated the roles of alternative markers in the prognoses of patients with PGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 101 patients who underwent curative treatment for PGC were retrospectively evaluated, and their 5\u2010year overall and disease\u2010free survival rates were calculated. The prognostic values of clinical and pathologic factors were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year overall and disease\u2010free survival rates were 73.1% and 62.8%, respectively. Multivariate analysis revealed that a low lymphocyte\u2010to\u2010monocyte ratio (LMR), high T classification, high N classification, and perineural invasion were independent predictors of poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thus, we identified LMR as an independent prognostic factor for patients with PGC. Patients with low LMRs who are amenable to treatment may require adjuvant treatment to improve their prognoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E864\u2013E869, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28934","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T17:19:32Z","timestamp":1594919972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic Value of the Lymphocyte\u2010to\u2010Monocyte Ratio in Patients with Parotid Gland Carcinoma"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-6214","authenticated-orcid":false,"given":"Takuya","family":"Mikoshiba","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Saiseikai Central Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Sekimizu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yoshihama","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihisa","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"},{"name":"Department of Otolaryngology, Head and Neck Surgery Kawasaki Municipal Kawasaki Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.02.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6990501"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0097-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2019.00388"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11254"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.668"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041658"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.785"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1559-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-52"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23823"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0226-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7378"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13440"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167967"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00207"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13565"},{"key":"e_1_2_6_19_1","volume-title":"AJCC Cancer Staging Mannual","author":"Edge SB","year":"2018"},{"key":"e_1_2_6_20_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2010.175"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5122-1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80312-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<2057::AID-CNCR24>3.0.CO;2-F"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.15692"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2019.03.006"},{"key":"e_1_2_6_27_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): Head and Neck cancers Version 3 2019. Sep 16 2019. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1931-5"},{"key":"e_1_2_6_29_1","first-page":"173","article-title":"Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes","volume":"47","author":"Rabinowich H","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077246"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3245"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1256"},{"key":"e_1_2_6_33_1","first-page":"4659","article-title":"Preoperative high neutrophil\u2010to\u2010lymphocyte ratio is associated with high\u2010grade bladder cancer","volume":"37","author":"Tang X","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1724600818817557"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816659257"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2228-y"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.28934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.28934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.28934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:25:42Z","timestamp":1693671942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.28934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/lary.28934"],"URL":"https:\/\/doi.org\/10.1002\/lary.28934","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"assertion":[{"value":"2020-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}