{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:45:01Z","timestamp":1779399901252,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Subglottic squamous cell carcinoma (SSCC) is a rare cancer with limited evidence\u2010based treatment guidelines. This study aimed to describe the treatment patterns for SSCC and to determine which treatments provide the best overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective database review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The National Cancer Database (NCDB) was queried for patients treated for SSCC from 2004 through 2014. Overall survival (OS) rates were determined by the Kaplan\u2010Meier method. Clinicopathologic characteristics were assessed by univariable and multivariable Cox proportional hazards models, which corrected for age, sex, race, insurance status, income quartile, residence, Charlson\u2010Deyo comorbidity score, facility type providing treatment, tumor grade, and clinical N and T category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this cohort of 549 patients with SSCC, the 5\u2010year OS was 48.2%. SSCC presented at an advanced stage (American Joint Committee on Cancer stage III or IV) in 60.1% of cases; 78.3% of cases had no nodal metastases. Among only stage IV cases, multivariable analysis showed that radiotherapy (RT) (hazard ratio [HR] =\u20095.944; 95% confidence interval [CI]: 2.76\u201012.8; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and chemoradiotherapy (CRT) (HR = 2.321; 95% CI: 1.36\u20103.97; <jats:italic>P<\/jats:italic> = .002) were both associated with decreased 5\u2010year OS compared to a group consisting of all surgeries. When this analysis was repeated for only stage III cases, RT (HR = 1.134; 95% CI: 0.38\u20103.37; <jats:italic>P<\/jats:italic> = .821) and CRT (HR = 1.784; 95% CI: 0.78\u20104.08; <jats:italic>P<\/jats:italic> = .170) were equivalent to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using the NCDB to study the largest cohort of SSCC with known staging and treatment, primary surgery may provide a better 5\u2010year OS in advanced\u2010stage SSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1117\u2013E1124, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28946","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:49:50Z","timestamp":1599072590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does Subglottic Squamous Cell Carcinoma Warrant a Different Strategy Than Other Laryngeal Subsites?"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-0478","authenticated-orcid":false,"given":"Mejd","family":"Jumaily","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative Medicine, and Pain Management Jackson Memorial Hospital, University of Miami Miller School of Medicine  Miami Florida U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Gallogly","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Saint Louis University School of Medicine  St. Louis Missouri U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Gropler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Saint Louis University School of Medicine  St. Louis Missouri U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-813X","authenticated-orcid":false,"given":"Farhoud","family":"Faraji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California San Diego Health  La Jolla California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Saint Louis University School of Medicine  St. Louis Missouri 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