{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:06:57Z","timestamp":1793383617419,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007363","name":"Stiftelsen Acta Oto-Laryngologica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004356","name":"Svensk F\u00f6rening f\u00f6r S\u00f6mnforskning och S\u00f6mnmedicin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether modified uvulopalatopharyngoplasty (UPPP) for treatment of obstructive sleep apnea (OSA) remained effective after 8\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective intervention study. Sixty\u2010five patients with OSA were offered re\u2010evaluation with polysomnography and the Epworth Sleepiness Scale (ESS) 8\u2009years after UPPP. Results were compared with baseline and with a previous 2\u2010year follow\u2010up. Baseline predictors were analyzed with regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dropout rate at the 8\u2010year follow\u2010up was 28%. The mean decrease in apnea\u2013hypopnea index (AHI) between baseline and the 8\u2010year follow\u2010up was significant, 14.0 events\/hour (from 52.9 to 38.9), 27% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The mean increase in AHI between the 2\u2010year and the 8\u2010year follow\u2010up was significant, 14.7 events\/hour (from 24.2 to 38.9), 61% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Overweight at baseline predicted an AHI at the 8\u2010year follow\u2010up that was 22.9 events higher compared to patients with normal weight (<jats:italic>P<\/jats:italic> = .015). An increase in body mass index (BMI) of 1\u2009kg\/m<jats:sup>2<\/jats:sup> between baseline and the 8\u2010year follow\u2010up predicted a mean AHI increase of 3.8 events\/hour (<jats:italic>P<\/jats:italic> = .015). The median decrease in ESS between baseline and the 8\u2010year follow\u2010up was significant, 7 (from 13.0 to 6.0), 54% (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The median increase in ESS between the 2\u2010year and the 8\u2010year follow\u2010up was not significant, 1.0 (from 5.0 to 6.0), 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Modified UPPP was effective as a long\u2010term treatment for OSA in selected patients, although the effect on AHI decreased over time. Daytime sleepiness remained improved even in the long term. High BMI at baseline and an increase in BMI predicted a reduced long\u2010term respiratory outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E307\u2013E313, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28960","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T15:56:05Z","timestamp":1595606165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Eight\u2010Year Follow\u2010up of Modified Uvulopalatopharyngoplasty in Patients With Obstructive Sleep Apnea"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-603X","authenticated-orcid":false,"given":"Joar","family":"Sundman","sequence":"first","affiliation":[{"name":"Division of ENT Diseases, Department of Clinical Sciences Intervention and Technology (CLINTEC) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"Browaldh","sequence":"additional","affiliation":[{"name":"Division of ENT Diseases, Department of Clinical Sciences Intervention and Technology (CLINTEC) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Fehrm","sequence":"additional","affiliation":[{"name":"Division of ENT Diseases, Department of Clinical Sciences Intervention and Technology (CLINTEC) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Friberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Institute of Surgical Science, Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Tonsillectomy with uvulopalatopharyngoplasty in obstructive sleep apnea","volume":"113","author":"Sommer UJ","year":"2016","journal-title":"Dtsch Arztebl 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