{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:32:39Z","timestamp":1777620759883,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IRIS Recherche","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Vesale Grant","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To assess the evolution of laryngeal and extralaryngeal symptoms and findings of laryngopharyngeal reflux (LPR) throughout a 3\u2010month to 9\u2010month treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective Controlled Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred twenty\u2010seven LPR patients and 123 healthy individuals were enrolled from four European hospitals. Patients were managed with a 3\u2010month personalized treatment considering the LPR characteristics at the impedance\u2010pH monitoring. Regarding the clinical therapeutic response, treatment was adapted for 3 to 6 additional months. Symptoms and findings were assessed throughout the therapeutic course with the Reflux Symptom Score (RSS) and the short version of the Reflux Sign Assessment (sRSA). The relationship between patient and reflux characteristics, symptoms, and findings was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred twenty\u2010one LPR patients completed the study. LPR patients exhibited more laryngeal and extralaryngeal symptoms and findings than healthy individuals. RSS significantly improved from baseline to 6\u2009weeks posttreatment and continued to improve from 3 months to 6 months posttreatment. sRSA significantly improved from baseline to 3 months posttreatment. No further improvement was noted at 6 months posttreatment for pharyngeal and oral findings. Laryngeal findings continued to improve from 3 months to 6 months posttreatment. There was a significant association between patient stress level and RSS (<jats:italic>P<\/jats:italic> = .045). At 3 months posttreatment, 28.1% of patients had high or complete response, whereas 47.1% required 6\u2009months or 9\u2009months of treatment. Overall, 24.8% of patients had an LPR chronic course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laryngeal and extralaryngeal symptoms and findings significantly improved throughout treatment in LPR patients. The improvement of laryngeal findings was slower. Regarding the low prevalence of some digestive or otolaryngological symptoms, a short version of the RSS could be developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:1332\u20131342, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28962","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T13:43:17Z","timestamp":1596634997000},"page":"1332-1342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Changes of Laryngeal and Extralaryngeal Symptoms and Findings in Laryngopharyngeal Reflux Patients"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R.","family":"Lechien","sequence":"first","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"},{"name":"Laboratory of Phonetics, Faculty of Psychology Research Institute for Language Sciences and Technology, University of Mons (UMons)  Mons Belgium"},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Saint\u2010Pierre University Hospital Center, Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Bobin","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Poitiers Polyclinic Elsan  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinciane","family":"Muls","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Gastroenterology and Endoscopy Saint\u2010Pierre University Hospital Center, Universit\u00e9 Libre de Bruxelles (ULB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Mouawad","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Lille University Hospital Center, Lille University 2  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Dapri","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Human Anatomy and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons)  Mons Belgium"},{"name":"Department of Surgery International School Reduced Scar Laparoscopy  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Dequanter","sequence":"additional","affiliation":[{"name":"Laryngopharyngeal Reflux Study Group of Young\u2010Otolaryngologists of the International Federations of Oto\u2010rhino\u2010laryngological Societies (YO\u2010IFOS)  Paris France"},{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Saint\u2010Pierre University Hospital Center, Universit\u00e9 Libre de Bruxelles (ULB)  Brussels 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