{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:32:55Z","timestamp":1773480775175,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the rate of lymph node metastasis in parotid gland acinar cell carcinoma, to identified factors associated with increased risk of metastasis, and to evaluate the effect of nodal metastasis on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study utilizing data from a large population\u2010based cancer database. Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 database. The study cohort included patients with parotid gland acinar cell carcinoma diagnosed between 2000 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall rate of lymph node metastasis was 6.8%. T3\/T4 (OR 6.17, 95% CI, 3.03 to 13.16) disease along with High Grade (OR 15.95) disease were associated with increased risk of nodal metastasis. Non\u2010white, non\u2010Black race was associated with decreased risk. Age and sex were not associated with nodal metastasis. Nodal metastasis was associated with worse OS (HR 6.27, 95% CI, 3.85 to 10.20) and DSS (HR 6.96, 95% CI, 3.81 to 12.73) after adjusting for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parotid gland acinar cell carcinoma carries a low risk of nodal metastasis. Both advanced T stage and high grade are associated with increased risk of nodal metastasis. Nodal metastasis is associated with decreased overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1125\u2013E1129, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28966","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T15:51:42Z","timestamp":1596901902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Significance of Nodal Metastasis in Parotid Gland Acinar Cell Carcinoma"],"prefix":"10.1002","volume":"131","author":[{"given":"Peter","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery School of Medicine, Stanford University  Palo Alto CA U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahbuba","family":"Tusty","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery School of Medicine, Stanford University  Palo Alto CA U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasu","family":"Divi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery School of Medicine, Stanford University  Palo Alto CA U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-8864","authenticated-orcid":false,"given":"Uchechukwu C.","family":"Megwalu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery School of Medicine, Stanford University  Palo Alto CA U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"AFIP Atlas of Tumor Pathology 4th Series: Tumors of the Salivary Gland","author":"Ellis GL","year":"2008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182841554"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1658-3876(09)50035-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830801)52:3<542::AID-CNCR2820520326>3.0.CO;2-A"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100087107"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199907)21:4<297::AID-HED2>3.0.CO;2-R"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(63)90416-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711480407"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196509)18:9<1145::AID-CNCR2820180915>3.0.CO;2-#"},{"key":"e_1_2_6_11_1","first-page":"401","article-title":"Surgical treatment of epithelial tumors of the parotid gland","volume":"97","author":"Buxton RW","year":"1953","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.7.720"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197803)41:3<924::AID-CNCR2820410321>3.0.CO;2-L"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178099"},{"key":"e_1_2_6_15_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. Incidence \u2010 SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases Nov 2018 Sub (1975\u20132016 varying). Available at:https:\/\/seer.cancer.gov\/data-software\/documentation\/seerstat\/nov2018\/. Accessed July 18 2019."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091315"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5711-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-015-3855-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0638"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.406"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2168"},{"key":"e_1_2_6_22_1","unstructured":"A randomized phase II\/phase III study of adjuvant concurrent radiation and chemotherapy versus radiation alone in resected high\u2010risk malignant salivary gland tumors. 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