{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:06:36Z","timestamp":1791234396895,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Familial non\u2010medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non\u2010medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively searched a database of 465 patients that underwent thyroidectomy at Assaf Harofeh Medical Center (91.4% between 1990 and 2019) for demographics, risk factors, medical history, diagnostic workup, primary treatment, follow\u2010up, and disease outcome data. We compared 47 FNMTC versus 321 SNMTC patients, and FNMTC patients with \u22652 (n = 34) versus \u22653 (n = 13) first\u2010relative affected members.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in demographics, histopathology, TNM stage, treatment, and disease outcome between the FNMTC and SNMTC groups. The T2 and T4 tumor stage in the \u22653\u2010member group were 25% and 8.3% compared to 0% and 0% in the two\u2010member group (<jats:italic>P<\/jats:italic> =\u2009.02 and <jats:italic>P\u2009=<\/jats:italic> ns, respectively). Also, LN involvement was significantly higher in the \u22653\u2010member group (61.6% vs. 24.2%, respectively; <jats:italic>P<\/jats:italic> =\u2009.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FNMTC is not a more aggressive disease than SNMTC, but this may not apply for the \u22653\u2010affected\u2010relatives group. A large multicenter study including only families with three or more affected relatives is needed. Until then, a family history of NMTC should not be overlooked.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3\/5 <jats:italic>Laryngoscope<\/jats:italic>, 131:E677\u2013E681, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28989","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T22:47:17Z","timestamp":1596754037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-6959","authenticated-orcid":false,"given":"Limor","family":"Muallem Kalmovich","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Jabarin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Koren","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Endocrine Institute Assaf Harofeh Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Or","sequence":"additional","affiliation":[{"name":"Endocrine Institute Assaf Harofeh Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Marcus","sequence":"additional","affiliation":[{"name":"Endocrine Institute Assaf Harofeh Medical Center  Zerifin 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