{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:11:49Z","timestamp":1775934709623,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID\u201019) infection were included. The presence of COVID\u201019 was detected by using real\u2010time polymerase chain reaction (RT\u2010PCR) methods. Positive and negative RT\u2010PCR patients were used as case and control groups, respectively.<\/jats:p><jats:p>This study analyzed the incidence of COVID\u201019 symptoms in both patient groups. Visual analog scales were used for self\u2010assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 215 (60.6%) patients with positive RT\u2010PCR and 140 (39.4%) patients with negative RT\u2010PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT\u2010PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45\u00b0C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14\u2009days of the onset of the symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a significant association between positive RT\u2010PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT\u2010PCR. The measurement of fever as the only method for screening of COVID\u201019 infection resulted in a poor association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 130:2674\u20132679, 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.28999","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T07:41:38Z","timestamp":1595230898000},"page":"2674-2679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prospective Study in 355 Patients With Suspected <scp>COVID<\/scp>\u201019 Infection: Value of Cough, Subjective Hyposmia, and Hypogeusia"],"prefix":"10.1002","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-3844","authenticated-orcid":false,"given":"Eduardo","family":"Martin\u2010Sanz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University Hospital of Getafe  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