{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:07:37Z","timestamp":1773288457747,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral lichen planus (OLP) is a chronic mucocutaneous immune\u2010mediated disease affecting 1% to 4% of the worldwide population. Development of malignant lesions is reported but only affects a minority of patients. The aim of our study was to assess the diagnostic potential of narrow band imaging (NBI) in OLP patients; focusing on the identification of high\u2010grade dysplasia\/carcinoma in newly developed lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective evaluation of 56 patients with histopathologic diagnosis of OLP and presenting newly developed lesions not responding to medical treatment. All lesions were assessed by high\u2010definition (HD) white light (WL) and HD\u2010NBI endoscopy. All patients underwent biopsy regardless of the appearance at HD\u2010WL and HD\u2010NBI. Histology was defined as \u201cpositive\u201d in case of high\u2010grade dysplasia or carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five lesions (9%) were diagnosed as high\u2010grade dysplasia\/carcinoma. In this setting, overall diagnostic potential of HD\u2010NBI was optimal, with a sensitivity of 100% (95% CI, 48\u2013100), specificity of 96% (95% CI, 86\u201399), negative predictive value of 100% (95% CI, not calculable), positive predictive value of 71% (95% CI, 39\u201391), and accuracy of 96% (95% CI, 88\u2013100).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the diffuse inflammatory pattern derived from OLP, NBI improved the diagnostic accuracy and the capability to detect high\u2010grade dysplasia\/carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1156\u2013E1161, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29035","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T06:46:15Z","timestamp":1597473975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-7333","authenticated-orcid":false,"given":"Alberto","family":"Deganello","sequence":"first","affiliation":[{"name":"Unit of Otorhinolaryngology\u2013Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia  Brescia 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Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bardellini","sequence":"additional","affiliation":[{"name":"Dental Clinic, School of Dentistry University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Majorana","sequence":"additional","affiliation":[{"name":"Dental Clinic, School of Dentistry University of Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2013Head and Neck Surgery, Department of Neurosciences University of Padua  Padua 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