{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:55:12Z","timestamp":1758808512707,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18410712400"],"award-info":[{"award-number":["18410712400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the clinical characteristics of papilloma involving the external auditory canal (PEAC) in a region of China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>A retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographics, manifestations, imaging results, histopathology, and treatment of 67 patients diagnosed with PEAC in a period of 6\u2009years were analyzed at Shanghai Eye, Ear, Nose and Throat Hospital in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PEAC were encountered in patients between the ages of 12 and 82\u2009years (mean 53.8\u2009years). It was more prevalent in men (82%) than in women (18%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The clinical presentation was usually a mass in EAC, aural fullness, and hearing loss. Otoscopic and radiological examination were used together for initial diagnosis and pretreatment planning. Unilateral involvement was more common than bilateral involvement (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The average time between onset of first symptom and surgical resection and\/or biopsy was 6.5\u2009months (range, 0.25\u201360\u2009months). All patients underwent gross total resection. In 5 patients, (7.5%) carcinoma was detected in the specimen. Fifteen patients (22%) had recurrence; recurrent tumors were detected after an average period of 10\u2009months after surgery (range, 4\u201324\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PEAC is largely a benign lesion with a low risk of malignancy. Optimal management is via gross total resection. However, the risk of recurrence is high, which motivates a need for long\u2010term monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:1132\u20131137, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29113","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T11:48:53Z","timestamp":1602157733000},"page":"1132-1137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Characteristics of Patients With Papilloma in the External Auditory Canal"],"prefix":"10.1002","volume":"131","author":[{"given":"Wenwei","family":"Luo","sequence":"first","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 200032 China"},{"name":"NHC Key Laboratory of Hearing Medicine (Fudan University)  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingfang","family":"Wu","sequence":"additional","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 200032 China"},{"name":"NHC Key Laboratory of Hearing Medicine (Fudan University)  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Peng","sequence":"additional","affiliation":[{"name":"House Institute  Los Angeles California 90057 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingzhong","family":"Li","sequence":"additional","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 200032 China"},{"name":"NHC Key Laboratory of Hearing Medicine (Fudan University)  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Du","sequence":"additional","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 200032 China"},{"name":"NHC Key Laboratory of Hearing Medicine (Fudan University)  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghong","family":"Xu","sequence":"additional","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 200032 China"},{"name":"NHC Key Laboratory of Hearing Medicine (Fudan University)  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfu","family":"Dai","sequence":"additional","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; ENT Hospital, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai 200031 China"},{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai 200032 China"},{"name":"NHC Key Laboratory of Hearing Medicine (Fudan University)  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-0393","authenticated-orcid":false,"given":"Fanglu","family":"Chi","sequence":"additional","affiliation":[{"name":"ENT institute and Department of Otorhinolaryngology, Eye &amp; 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