{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:23:06Z","timestamp":1781011386396,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is associated with a significant decrease in general health\u2010related quality of life (QOL). The EuroQol 5\u2010dimensional questionnaire measures general health\u2010related quality of life through a health utility value (EQ\u20105D HUV)\u2014based on five domains reflecting mobility, self\u2010care, activities of daily life, pain\/discomfort, and anxiety\/depression\u2014and an unbiased visual analog scale (EQ\u20105D VAS). We sought to identify characteristics of CRS patients with a high EQ\u20105D HUV but low EQ\u20105D VAS score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Retrospective cross\u2010sectional study of 300 CRS patients with EQ\u20105D HUV equal to 1.0 (reflecting perfect health). All patients completed a 22\u2010item Sinonasal Outcome Test (SNOT\u201022)\u2014from which nasal, sleep, ear\/facial discomfort, and emotional subdomain scores were calculated, as well as the EQ\u20105D. Low EQ\u20105D VAS was defined as a score less than 80.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariate analysis, low EQ\u20105D VAS was associated with only the SNOT\u201022 sleep subdomain score (odds ratio [OR] = 1.07, 95%CI: 1.02\u20131.12, <jats:italic>P<\/jats:italic> = .003). Comorbid asthma was also associated with lower EQ\u20105D VAS (OR = 2.16, 95%CI: 1.02\u20134.59, <jats:italic>P<\/jats:italic> = .045). In contrast, polyps were negatively associated with having a lower EQ\u20105D VAS (OR = 0.34, 95%CI: 0.17\u20130.69, <jats:italic>P<\/jats:italic> = .003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are patients with perfect general health\u2010related QOL according to a health utility value\u2010based methodology (like the EQ\u20105D HUV) who report low general health\u2010related QOL on an unbiased measure like the EQ\u20105D VAS. In CRS patients with perfect EQ\u20105D HUV, poor sleep and asthma were associated with low QOL on the EQ\u20105D VAS, while polyps were negatively associated with low QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:1206\u20131211, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29139","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T12:18:45Z","timestamp":1601641125000},"page":"1206-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Unbiased Measure of General Quality of Life in Chronic Rhinosinusitis Reveals Disease Modifiers"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-5111","authenticated-orcid":false,"given":"Madison V.","family":"Epperson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-3508","authenticated-orcid":false,"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Caradonna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Division of Otolaryngology Beth Israel Deaconess Medical Center  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School  Boston Massachusetts U.S.A."},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary  Boston Massachusetts U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"S209","article-title":"International consensus statement on allergy and rhinology: Rhinosinusitis","volume":"6","author":"Orlandi 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