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Here, we review the biology and immunology of low\u2010risk human papillomavirus (HPV) infections. Antiviral or antiangiogenic adjuvant treatments similarly address the papillomatous disease itself but do not activate HPV immunity. It is likely that only through immune\u2010mediated clearance of low\u2010risk HPV infection can patients with RRP be cured. In some patients, this occurs spontaneously. In others with more aggressive disease, adjuvant immunotherapy to activate immunity may be needed. Based on current understanding of antiviral immune responses, the only rational strategy to clear HPV\u2010infected epithelial cells is through activation of the T\u2010lymphocyte arm of the adaptive immune response. Translation of immunotherapies that are Food and Drug Administration\u2010approved or under clinical study for cancer, such as immune checkpoint blockade or engineered therapeutic vaccines, may provide a path toward tolerable and efficacious adjuvant immunotherapy for RRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 131:2041\u20132047, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29153","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T10:33:00Z","timestamp":1615804380000},"page":"2041-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["How Enhancing Immunity to Low\u2010Risk <scp>HPV<\/scp> Could Cure Recurrent Respiratory Papillomatosis"],"prefix":"10.1002","volume":"131","author":[{"given":"Ke","family":"Bai","sequence":"first","affiliation":[{"name":"Section on Translation Tumor 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