{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:57:29Z","timestamp":1773791849192,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Ultrasound\u2010guided fine\u2010needle aspiration cytology (US\u2010FNAC) is a well\u2010established procedure performed to establish the diagnosis of Kikuchi\u2010Fujimoto disease (KFD). Ultrasound\u2010guided core needle biopsy (US\u2010CNB) is an alternative diagnostic tool for KFD. However, the efficacy of US\u2010CNB is not well evaluated. This study aimed to evaluate the efficacy of US\u2010CNB and compare it with that of US\u2010FNAC in the diagnosis of KFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 170 patients who were diagnosed with KFD between January 2009 and May 2019. US\u2010FNAC, US\u2010CNB, and excisional biopsy were performed in 47, 114, and 9 patients, respectively. Diagnostic accuracies of US\u2010FNAC and US\u2010CNB were analyzed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 170 patients, 45 and 125 were men and women, respectively. The mean age was 26.9\u2009\u00b1\u20099.1\u2009years. The most common symptom was cervical lymphadenopathy, followed by fever, headache, and myalgia. The diagnosis of KFD was established primarily by US\u2010FNAC in 21 (44.7%) of the 47 patients, by US\u2010CNB in 109 (95.6%) of the 114 patients, and by excisional biopsy in all 9 patients. There was no specific major complication related to US\u2010FNAC and US\u2010CNB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>US\u2010CNB can be considered safe and effective and used as the primary modality for the pathological diagnosis of KFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 131:E1519\u2013E1523, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29160","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:23:09Z","timestamp":1601572989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of Ultrasound\u2010Guided Needle Biopsy in the Diagnosis of Kikuchi\u2010Fujimoto Disease"],"prefix":"10.1002","volume":"131","author":[{"given":"Sang Gyu","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, College of Medicine Hanyang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Ryoung","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine Hanyang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiseok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Hanyang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kyung","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Hanyang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Myeon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, College of Medicine Hanyang University  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