{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:42:02Z","timestamp":1778596922924,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["CBET#184710"],"award-info":[{"award-number":["CBET#184710"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001325","name":"San Antonio Area Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Novel laryngotracheal wound coverage devices are limited by complex anatomy, smooth surfaces, and dynamic pressure changes and airflow during breathing. We hypothesize that a bioinspired mucoadhesive patch mimicking how geckos climb smooth surfaces will permit sutureless wound coverage and also allow drug delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p><jats:italic>ex\u2010vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Polycaprolactone (PCL) fibers were electrospun onto a substrate and polyethylene glycol (PEG) \u2013 acrylate flocks in varying densities were deposited to create a composite patch. Sample topography was assessed with laser profilometry, material stiffness with biaxial mechanical testing, and mucoadhesive testing determined cohesive material failure on porcine tracheal tissue. Degradation rate was measured over 21\u2009days in vitro along with dexamethasone drug release profiles. Material handleability was evaluated via suture retention and in cadaveric larynges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased flocking density was inversely related to cohesive failure in mucoadhesive testing, with a flocking density of PCL\u2010PEG\u20102XFLK increasing failure strength to 6880\u2009\u00b1\u20091810\u2009Pa compared to 3028\u2009\u00b1\u2009791 in PCL\u2010PEG\u20104XFLK density and 1182\u2009\u00b1\u2009262 in PCL\u2010PEG\u20106XFLK density. The PCL\u2010PEG\u20102XFLK specimens had a higher failure strength than PCL alone (1404\u2009\u00b1\u2009545\u2009Pa) or PCL\u2010PEG (2732\u2009\u00b1\u2009840). Flocking progressively reduced composite stiffness from 1347\u2009\u00b1\u200915 to 763\u2009\u00b1\u200921\u2009N\/m. Degradation increased from 12% at 7\u2009days to 16% after 10\u2009days and 20% after 21\u2009days. Cumulative dexamethasone release at 0.4\u2009mg\/cm<jats:sup>2<\/jats:sup> concentration was maintained over 21\u2009days. Optimized PCL\u2010PEG\u20102XFLK density flocked patches were easy to maneuver endoscopically in laryngeal evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel, sutureless, patch is a mucoadhesive platform suitable to laryngeal and tracheal anatomy with drug delivery capability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 131:1958\u20131966, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29182","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T14:41:18Z","timestamp":1604068878000},"page":"1958-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of a Bioinspired, <scp>Self\u2010Adhering,<\/scp> and <scp>Drug\u2010Eluting<\/scp> Laryngotracheal Patch"],"prefix":"10.1002","volume":"131","author":[{"given":"Solaleh","family":"Miar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at San Antonio  San Antonio Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-3104","authenticated-orcid":false,"given":"Gregory R.","family":"Dion","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at San Antonio  San Antonio Texas U.S.A."},{"name":"Dental and Craniofacial Trauma Research Department U.S. Army Institute of Surgical Research  San Antonio Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Montelongo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at San Antonio  San Antonio Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo L.","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at San Antonio  San Antonio Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena","family":"Bizios","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at San Antonio  San Antonio Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teja","family":"Guda","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Texas at San Antonio  San Antonio Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810769"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2010.06.022"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05742-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivt326"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0218492319827439"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225377.33945.14"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23949"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.02.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.043"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.0088"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.03.03"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.11.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05968"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.1205"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0040517507081283"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2820755"},{"key":"e_1_2_7_20_1","first-page":"1819","article-title":"Millimeter size patch behavior of gecko\u2010inspired reversible adhesive","author":"Tamelier J","year":"2011","journal-title":"Sensors IEEE"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA11937E"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm04502k"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA24922A"},{"key":"e_1_2_7_24_1","first-page":"86","article-title":"Preparation of gentamicin sulfate eluting fiber mats by emulsion and by suspension electrospinning","volume":"94","author":"Coimbra P","year":"2019","journal-title":"Korean J Couns Psychother"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-45433-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.03.047"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.09.004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.10.026"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.05.037"},{"key":"e_1_2_7_30_1","first-page":"111","article-title":"The controlled release of dexamethasone sodium phosphate from bioactive electrospun PCL\/gelatin Nanofiber scaffold","volume":"18","author":"Rasti Boroojen F","year":"2019","journal-title":"Iran J Pharm Res"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2019.05.010"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.01.043"},{"key":"e_1_2_7_33_1","first-page":"1741","article-title":"Chitosan imparts better biological properties for poly (\u03b5\u2010caprolactone) electrospun membranes than dexamethasone","volume":"30","author":"Machado BR","year":"2019","journal-title":"J Braz Chem Soc"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma5030540"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.08.022"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.11.028"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2011.02.012"},{"key":"e_1_2_7_38_1","first-page":"121","article-title":"Suture retention strength of expanded polytetrafluoroethylene (ePTFE) graft","volume":"64","author":"Mine Y","year":"2010","journal-title":"Acta Med Okayama"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA04529E"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.08.001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.08.021"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300418"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2020.01.21"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.012"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116001122"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26682"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26874"},{"key":"e_1_2_7_48_1","first-page":"1","article-title":"Surgical management of acquired anterior glottic web: a systematic review","author":"Fussey JM","year":"2019","journal-title":"J Laryngol Otol"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27715"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27531"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712117105"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-31049-5_12"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2011.12.012"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.76478"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181820896"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00738"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/lary.29182","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:24:32Z","timestamp":1693279472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/lary.29182"],"URL":"https:\/\/doi.org\/10.1002\/lary.29182","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]},"assertion":[{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}