{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:14:03Z","timestamp":1789748043587,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Hypopharyngeal squamous cell carcinoma (SCC) is a rare but aggressive malignancy, with low survival rates and high incidence of tumor and treatment\u2010related morbidity. This study aims to analyze the long\u2010term oncologic and functional outcomes of a large cohort of patients and to determine prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The records of all patients diagnosed with hypopharyngeal SCC and treated with curative intent at our tertiary referral center were reviewed. Patient and initial disease characteristics, features, and complications of primary treatment, recurrence patterns, and corresponding treatments and the oncologic and functional long\u2010term outcome were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For a total of 179 patients, primary radiotherapy (RT) was the predominant treatment modality (78%), whereas 22% underwent primary surgery. The median, 2\u2010year, and 5\u2010year overall survival (OS) for the study cohort were 47\u2009months, 64% and 43%. The median survival after first and second relapse was 7 and 6\u2009months, respectively. The 2 and 5\u2010year relapse\u2010free survival (RFS) was 52% and 36%. The median RFS after first relapse and salvage treatment was 9 months. A nodal status of \u2265cN2 (HR = 1.89, CI:1.21\u20133.05, <jats:italic>P<\/jats:italic> &lt;\u2009.005) and any other primary tumor localization than pyriform sinus (HR = 1.60, CI: 1.04\u20132.42, <jats:italic>P<\/jats:italic> &lt;\u2009.05) were identified as independent risk factors for shorter OS and RFS. Regarding functional outcome, the 2\u2010 and 5\u2010year laryngectomy\u2010free\u2010survival was 55% and 37%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large cohort with long\u2010term follow\u2010up, any other primary tumor localization than pyriform sinus and a nodal status of \u2265cN2 were identified as risk factors for reduced OS and RFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1543\u2013E1549, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29186","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T12:41:31Z","timestamp":1603543291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Predicting Factors for Oncological and Functional Outcome in Hypopharyngeal Cancer"],"prefix":"10.1002","volume":"131","author":[{"given":"Miranda","family":"Visini","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-3210","authenticated-orcid":false,"given":"Roland","family":"Giger","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Shelan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olgun","family":"Elicin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-0664","authenticated-orcid":false,"given":"Lukas","family":"Anschuetz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215118000555"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22742"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3880-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyv163"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21613"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds065"},{"key":"e_1_2_6_8_1","first-page":"djv368","article-title":"Long\u2010term results of a multicenter randomized phase III trial of induction chemotherapy with Cisplatin, 5\u2010fluorouracil, \u00b1 Docetaxel for larynx preservation","volume":"108","author":"Janoray G","year":"2015","journal-title":"JNCI: J Natl Cancer 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