{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:46:49Z","timestamp":1766407609003,"version":"3.40.5"},"reference-count":88,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The objective of this meta\u2010analysis was to look at the pooled prevalence of symptoms, laboratory tests, and imaging of all COVID\u201019 infected patients. This will allow better identification of potential COVID\u201019 patients and take appropriate precautions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Meta analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched three databases, PubMed, EMBASE, and Ovid to identify studies published between Dec\u20102019 and May\u20102020. All studies reporting upper\u2010aerodigestive symptoms of COVID\u201019 infection were included. The meta\u2010analysis was conducted following meta\u2010analyses of observational studies in epidemiology (MOOSE) guidelines, which have evaluated the pooled prevalence of 14 symptoms and nine laboratory investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on inclusion criteria, 67 publications consisting of 8302 patients were included. Among adults, the pooled proportion of hypertensive and diabetic patients was 18% and 7%. Cough (53% [0.46\u20130.61]), anosmia (38% [0.19\u20130.58]), loss\/distortion of taste (31% [0.17\u20130.45]), and nasal obstruction (26% [0.12\u20130.39]) were the most common ear, nose &amp; throat (ENT) symptoms. Fever (69% [0.62\u20130.76]) and fatigue (31% [0.26\u20130.37]) were the commonest generalized symptoms. C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were raised in 56% (0.41\u20130.71) and 49% (0.21\u20130.77), respectively. Interestingly, lymphopenia (41% [0.30\u20130.53]) and leucopenia (22% [0.16\u20130.29]) were more common than lymphocytosis (33% [0.02\u20130.64]) and leucocytosis (12% [0.09\u20130.16]). Fever (69% vs. 44%), cough (53% vs. 33%), and dyspnea (20% vs. 4%) were more common in adults as compared to the pediatric population. Diarrhea was more common among the pediatric cases (12%) versus (9%). The pooled estimate of fatality was 4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most commonly experienced ENT symptom was cough followed by anosmia and dysguesia. Raised ESR and CRP with leukopenia and lymphopenia are common laboratory findings. Majority of the infected patients had abnormal computed tomography findings. COVID infection is less severe in pediatric patients. <jats:italic>Laryngoscope<\/jats:italic>, 131:1254\u20131265, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29207","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T09:33:05Z","timestamp":1602927185000},"page":"1254-1265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Meta\u2010Analysis of 67 Studies with Presenting Symptoms and Laboratory Tests of <scp>COVID<\/scp>\u201019 Patients"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-2738","authenticated-orcid":false,"given":"Manish","family":"Mair","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University Hospitals of Leicester  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-0951","authenticated-orcid":false,"given":"Hitesh","family":"Singhavi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Services\/Department of Medicine Fortis Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameya","family":"Pai","sequence":"additional","affiliation":[{"name":"Head and Neck Services Tata Memorial Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinesh","family":"Singhavi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Services\/Department of Medicine Fortis Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Neonatology University Hospital of Leicester  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Conboy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospitals of Leicester  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospitals of Leicester  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudip","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University Hospitals of Leicester  United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"157","article-title":"WHO declares COVID\u201019 a pandemic","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Biomed"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_6_4_1","unstructured":"WHO Coronavirus Disease (COVID\u201019) dashboard. 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