{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:32:32Z","timestamp":1769106752966,"version":"3.49.0"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST108\u20102314\u2010B\u2010002\u2010181\u2010MY3"],"award-info":[{"award-number":["MOST108\u20102314\u2010B\u2010002\u2010181\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008904","name":"Taipei Hospital","doi-asserted-by":"publisher","award":["202002"],"award-info":[{"award-number":["202002"]}],"id":[{"id":"10.13039\/100008904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate associations between sleep surgery and CRP (C\u2010reactive protein) levels in adults with obstructive sleep apnea (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two authors independently searched PubMed, Medline, EMBASE, and Cochrane review databases until July 2019. The keywords used were sleep apnea, OSA, sleep apnea syndromes, surgery, C\u2010reactive protein (CRP), and inflammatory markers. The effects of sleep surgery on CRP levels were examined using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies with 277 patients were analyzed (mean age: 46.5\u2009years; 92% men; mean sample size: 30.8 patients). The mean change in the apnea\u2013hypopnea index (AHI) after surgery was significantly reduced by \u221221.1 (95% confidence interval [CI], \u221228.4 to \u221213.7) events\/hr. Overall, sleep surgery resulted in a significant reduction of CRP levels in patients with OSA (standardized mean difference [SMD] = \u22120.39, 95% CI, \u22120.67 to \u22120.11). Patients with postoperative AHI reduction &gt;20 events\/hr achieved a greater reduction in CRP than those with AHI reduction &lt;20 events\/hr (SMD: \u22120.72 vs. \u22120.14, <jats:italic>P<\/jats:italic> for heterogeneity = .007). According to subgroup analysis, differences in the CRP levels after surgery were nonsignificant in the different countries (i.e., United States vs. other countries), CRP types (i.e., CRP vs. high\u2010sensitivity CRP), surgical procedures (i.e., pharyngeal surgery vs. other surgical procedures), and follow\u2010up period (i.e., &lt;6 vs. &gt;6\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep surgery for OSA resulted in a significant reduction of CRP levels in adults. The beneficial effect of surgery on CRP levels is greater in patients with large improvement in OSA (i.e., AHI reduction &gt;20 events\/hr) after sleep surgery. <jats:italic>Laryngoscope<\/jats:italic>, 131:1180\u20131187, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29212","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T14:08:10Z","timestamp":1603894090000},"page":"1180-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Sleep Surgery on C\u2010Reactive Protein Levels in Adults With Obstructive Sleep Apnea: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-9261","authenticated-orcid":false,"given":"Kun\u2010Tai","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Taipei Hospital, Ministry of Health and Welfare  New Taipei City Taiwan"},{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te\u2010Huei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology College of Medicine, National Taiwan University  Taipei Taiwan"},{"name":"Sleep Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Shuo","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Shin Kong Wu\u2010Ho\u2010Su Memorial Hospital  Taipei Taiwan"},{"name":"School of Medicine Fu Jen Catholic University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenq\u2010Yuh","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology College of Medicine, National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hsuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Taipei Hospital, Ministry of Health and Welfare  New Taipei City Taiwan"},{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Nursing Hsin Sheng Junior College of Medical Care and Management  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Tzer","family":"Lin","sequence":"additional","affiliation":[{"name":"Sleep Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine Hsiao Chung\u2010Cheng Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-8459","authenticated-orcid":false,"given":"Wei\u2010Chung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology College of Medicine, National Taiwan University  Taipei Taiwan"},{"name":"Sleep Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.111.000091"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.080"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000053730.47739.3C"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3070"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002454"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006850"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2019.1600025"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9807111"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812451840"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0722-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.07.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-018-1662-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.01.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818813337"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.1656"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8222"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.09.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_6_22_1","unstructured":"WellsGA SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analysis. Available at:http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9694-x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00234-2016"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.07.004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.10.066"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20946"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810395104"},{"key":"e_1_2_6_30_1","first-page":"207","article-title":"Influence of uvulopalatopharyngoplasty on serum uric acid level in obstructive sleep apnea patients","volume":"40","author":"Zheng YL","year":"2016","journal-title":"Lab Medizin"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0887-8"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-4290-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131709600208"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.06.173"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.4.461"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.04.001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032804"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61717-7"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018948.95175.03"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0492-2"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.46.801"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-019-00237-0"},{"key":"e_1_2_6_44_1","first-page":"CD001106","article-title":"Continuous positive airways pressure for obstructive sleep apnoea in adults","author":"Giles TL","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0136-4"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0156-0"},{"key":"e_1_2_6_48_1","first-page":"CD001004","article-title":"Surgery for obstructive sleep apnoea","author":"Sundaram S","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3558"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006008"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900609"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20634"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3475-7"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816422ea"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27597"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.11.003"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.2678"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25847"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24433"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308659"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25032"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.10.1396"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.12.1537"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816661481"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.02.030"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201493"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.088"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-016-1319-y"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7967"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.102117"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819840356"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.03.017"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.05.001"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:31:39Z","timestamp":1693618299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/lary.29212"],"URL":"https:\/\/doi.org\/10.1002\/lary.29212","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2020-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}