{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:40:16Z","timestamp":1782135616439,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Mal de d\u00e9barquement syndrome (MDDS) is characterized by a persistent rocking sensation, as though on a boat. It may occur following exposure to passive motion (motion\u2010triggered MDDS [MT\u2010MDDS]), or spontaneously (spontaneous\u2010onset MDDS [SO\u2010MDDS]). This study investigated the characteristics of MDDS patients with vestibular migraine (MDDS\u2010VM) to those without (MDDS\u2010O).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, single\u2010center study of 62 patients with MDDS. Clinical characteristics, Dizziness Handicap Inventory (DHI), Migraine Disability Assessment Score (MIDAS), job impact, and optimal treatment(s) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 23 MDDS\u2010O (19 women), and 39 MDDS\u2010VM (35 women) patients. Comparisons between MDDS\u2010VM and MDDS\u2010O showed significant differences in age of onset (41 vs. 52\u2009years, <jats:italic>P<\/jats:italic> = .005), interictal visually induced dizziness (89.7% vs. 30.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), interictal head motion\u2010induced dizziness (87.2% vs. 47.8%, <jats:italic>P<\/jats:italic> = .001), other vestibular sensations (59% vs. 13%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), interictal aural symptoms (25.6% vs. 0%, <jats:italic>P\u2009=<\/jats:italic> .008), number of interictal symptoms (4.3 vs. 2.3, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), total DHI score (54.9 vs. 38.1, <jats:italic>P<\/jats:italic> = .005), DHI\u2010P (physical domain) score (16.1 vs. 10, <jats:italic>P<\/jats:italic> = .004), DHI\u2010F (functional domain) score (20.9 vs. 15.7, <jats:italic>P<\/jats:italic> = .016 MIDAS (4.6 vs. 32, <jats:italic>P<\/jats:italic> = .002), and job resignations (23.2% vs. 5%, <jats:italic>P<\/jats:italic> = .016). On the other hand, between\u2010group comparisons for MT\u2010MDDS and SO\u2010MDDS did not reveal any significant differences whatsoever. For optimal treatment, venlafaxine was the most used (27.3%) in all groups. For MDDS\u2010VM, antiepileptic drugs and migraine preventive vitamins were also useful in relieving symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MDDS\u2010VM patients appear to be more disabled than MDDS\u2010O, in terms of severity of dizziness, job impact, and number of symptoms, but have good potential for improvement, particularly with migraine prophylactic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1653\u2013E1661, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29214","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T11:04:45Z","timestamp":1604315085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Interconnections of Mal de D\u00e9barquement Syndrome and Vestibular Migraine"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-9953","authenticated-orcid":false,"given":"Shin C.","family":"Beh","sequence":"first","affiliation":[{"name":"Department of Neurology University of Texas Southwestern Medical Center  Dallas Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh\u2010Sheng","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern Medical Center  Dallas Texas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern Medical Center  Dallas Texas 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