{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:32Z","timestamp":1786978172493,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"publisher","award":["MMH\u2010108\u2010104"],"award-info":[{"award-number":["MMH\u2010108\u2010104"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sarcopenia and systemic inflammation can affect survival of advanced\u2010stage oral squamous cell carcinoma (OSCC) patients; however, their reciprocal associations with survival outcomes are yet to be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective review at a tertiary cancer center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with stage III\u2010IVB OSCC that underwent surgery and (chemo)radiotherapy at our institution between 2010 and 2015 were reviewed. Skeletal muscle index (SMI) was assessed using computed tomography scans at the C3 vertebra. Sarcopenia was defined at the lowest sex\u2010specific tertile for SMI. Systemic inflammation was estimated using the modified Glasgow prognostic score (mGPS), which ranges from 0 to 2 based on serum C\u2010reactive protein and albumin levels. The predictors of overall survival (OS) were evaluated using Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 174 patients were included in the study. The cut\u2010off values for sarcopenia were set at SMI &lt;52.4\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      (men) and\u2009&lt;\u200936.2\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      (women) corresponding to the lowest sex\u2010specific tertile. An mGPS 1\u20132 was independently associated with sarcopenia (odds ratio: 2.05; 95% confidence interval: 1.06\u20133.97;\n                      <jats:italic>P<\/jats:italic>\n                      = .03). On multivariate analysis for OS, sarcopenia and mGPS 1\u20132 independently predicted OS (hazard ratio: 2.12; 95% confidence interval: 1.17\u20133.85;\n                      <jats:italic>P<\/jats:italic>\n                      = .01 and hazard ratio: 7.85; 95% confidence interval: 3.7\u201316.65;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001, respectively). Patients with both sarcopenia and mGPS 1\u20132 (vs. neither) had worse OS (hazard ratio: 16.80; 95% confidence interval: 6.01\u201346.99;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia and systemic inflammation may exert a negative synergistic prognostic impact in advanced\u2010stage OSCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 131:E1530\u2013E1538, 2021\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.29221","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T06:50:08Z","timestamp":1604299808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Sarcopenia and Systemic Inflammation Synergistically Impact Survival in Oral Cavity Cancer"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-2393","authenticated-orcid":false,"given":"Jie","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medicine MacKay Medical College  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology MacKay Memorial Hospital  Taipei 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