{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:30:36Z","timestamp":1747150236347,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>When conservative therapy fails for chronic parotitis, sialendoscopic treatment or surgical excision can be considered. However, these are financially costly or invasive. Thus, this study aimed to evaluate the clinical efficacy and safety of botulinum toxin (BTX) injection and to further analyze its effect on parotid gland function and volume using salivary single\u2010photon emission computed tomography (SPECT)\u2010computed tomography (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This clinical trial has been registered in the Clinical Research Information Service, Republic of Korea. Fourteen patients with chronic parotitis received BTX injections into the parotid glands. Pain, postprandial pain, swelling, aesthetic discomfort, and salivary flow rate were assessed before injection, at 2\u2009weeks, and at 1, 3, and 6\u2009months. Salivary SPECT\u2013CT was performed before injection and again 3 and 6\u2009months after to assess the volume and uptake changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjective symptoms decreased significantly until 1\u2009month and then increased. However, at 6\u2009months, all subjective symptoms were determined to be better than before injection. The unstimulated and stimulated salivary flow rate did not show a significant difference over time. No significant difference was noted in parotid gland volume or uptake on salivary SPECT\u2013CT over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BTX injection can be an alternative treatment option for chronic parotitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1903\u2013E1909, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29225","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T14:21:12Z","timestamp":1603894872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Botulinum Toxin Injection for Chronic Parotitis: A Multi\u2010Center and Prospective Trial"],"prefix":"10.1002","volume":"131","author":[{"given":"Soon Young","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Korea University Ansan Hospital  Ansan Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Ju","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Kwon","family":"Kil","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-5905","authenticated-orcid":false,"given":"Kyoung Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Korea University Ansan Hospital  Ansan Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chulhan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea University Ansan Hospital  Ansan Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-4174","authenticated-orcid":false,"given":"Min\u2010Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Gyeonggi\u2010do Republic of 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