{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:40:26Z","timestamp":1770990026020,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>This study is a systematic review of the literature which seeks to estimate the expected treatment outcomes of a patient with Sjogren's syndrome (SS) undergoing therapeutic sialendoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Systematic Review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Scopus, and Cochrane library databases were used to search for studies published as of August 2020 regarding the treatment outcomes of SS with sialendoscopy. The key search terms included \u201cSjogren's syndrome\u201d and \u201csialendoscopy.\u201d Only studies in the English language involving more than one human patient were included. PRISMA guidelines were followed in study inclusion and data extraction. The primary outcome assessed was improvement in patient symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies met criteria and were analyzed in this review, including 125 patients undergoing sialendoscopy of parotid and\/or submandibular glands as well as 25 controls. Of these patients, 90% were female with an age range of 18 to 79\u2009years. There was significant diversity in outcome reporting tools. The outcomes of symptom improvement were pooled qualitatively based on improvement noted in each study. Outcomes were defined as partial improvement if the measured outcomes improved and complete improvement if measured outcomes resolved entirely. Despite the limited number of studies on this topic, this meta\u2010analysis suggests that a similar study of therapeutic sialendoscopy could expect to provide at least temporary improvement of symptoms 90% to 99% of the time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review provides support for the application of sialendoscopy in the treatment of SS salivary disease. Larger studies with consistent outcome reporting tools and control groups are needed to validate these results and provide a consistent therapy protocol. <jats:italic>Laryngoscope<\/jats:italic>, 131:1474\u20131481, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29233","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T18:10:45Z","timestamp":1604427045000},"page":"1474-1481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sialendoscopy and Sjogren's Disease: A Systematic Review"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-9076","authenticated-orcid":false,"given":"Kimberly K.","family":"Coca","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Boyd","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-2462","authenticated-orcid":false,"given":"Nicholas A.","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongshun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics \u2013 Department of Preventive Medicine University of Tennessee Health Science Center  Memphis Tennessee U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara M.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Medical Library Research and Learning Services University of Tennessee Health Science Center  Memphis Tennessee U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-6596","authenticated-orcid":false,"given":"Robert L.","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Thomas Jefferson University  Philadelphia Pennsylvania U.S.A."},{"name":"Delaware ENT\u2010Head and Neck Surgery Christiana Care  Wilmington Delaware U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13192"},{"key":"e_1_2_6_3_1","first-page":"247","article-title":"The epidemiology of Sj\u00f6gren's syndrome","volume":"6","author":"Patel R","year":"2014","journal-title":"Clin Epidemiol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210571"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_6_6_1","unstructured":"The University of Oxford Center for Evidence Based Medicine 2016. 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