{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:06:18Z","timestamp":1793210778603,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The pathophysiology of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown, but labyrinthine artery infarction has been proposed. The objective of this study was to perform a systematic review and conduct a meta\u2010analysis assessing the risk of developing stroke and myocardial infarction after presentation with ISSNHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature review was conducted using Pubmed, Embase, Web of Science, and Cochrane Libraries. All studies investigating an association between ISSNHL and stroke and\/or myocardial infarction (MI) were included. Adhering to the MOOSE guideline, two independent reviewers extracted data, assessed risk of bias, and evaluated the relevance and quality of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three observational studies evaluating the risk of stroke in ISSNHL were included (n = 6,521 patients). All individual study results indicated an increased relative risk of stroke after ISSNHL (unadjusted relative risk range 1.21\u20131.63). Pooled adjusted hazard ratios revealed a 1.42\u2010fold increased risk of stroke after ISSNHL (hazard ratio [HR] 1.42; 95% confidence interval [CI] 1.15\u20131.75, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> =\u200955%). Subgroup analysis of one study demonstrated that the increased risk is only present in adults aged above 50\u2009years (HR 1.23; 95% CI 1.07\u20131.42). Five observational studies evaluating the risk of MI in patients with ISSNHL were included (n = 61,499 patients). Pooled analyses demonstrated that ISSNHL was not associated with MI (HR 1.08, 95% CI 0.87\u20131.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ISSNHL may be an independent risk factor for the subsequent development of stroke especially in a subgroup of elderly patients. More studies are needed to confirm this association and to assess whether such patients would benefit from cardiovascular risk assessment and management to prevent future strokes. <jats:italic>Laryngoscope<\/jats:italic>, 131:1369\u20131377, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29237","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T17:49:16Z","timestamp":1604684956000},"page":"1369-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk of Stroke and Myocardial Infarction After Sudden Sensorineural Hearing Loss: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-3863","authenticated-orcid":false,"given":"Marc J. W.","family":"Lammers","sequence":"first","affiliation":[{"name":"BC Rotary Hearing and Balance Centre at St. Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Young","sequence":"additional","affiliation":[{"name":"BC Rotary Hearing and Balance Centre at St. Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Westerberg","sequence":"additional","affiliation":[{"name":"BC Rotary Hearing and Balance Centre at St. Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Lea","sequence":"additional","affiliation":[{"name":"BC Rotary Hearing and Balance Centre at St. Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812436449"},{"key":"e_1_2_6_3_1","first-page":"69","article-title":"The etiology of idiopathic sudden sensorineural hearing loss. A review of the literature","volume":"50","author":"Stokroos RJ","year":"1996","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20873"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016484409119921"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.00857"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000207"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946907800413"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900408"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(88)80036-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100103"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009121137"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.519090"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23837"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341988"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22480"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.01.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26514"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2012.705904"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.2569"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19404-z"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001902"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001868"},{"key":"e_1_2_6_24_1","first-page":"CD003998","article-title":"Steroids for idiopathic sudden sensorineural hearing loss","volume":"7","author":"Wei BPC","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200603210-00010"},{"key":"e_1_2_6_28_1","unstructured":"Sch\u00fcnemannH Bro\u017cekJ GuyattG OxmanA.GRADE handbook. Available at:https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html. Accessed March 15 2019."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.10.024"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117001736"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1297537"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162629"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004841"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318181336c"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.09.033"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23689"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001967"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121025"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540870515"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600406"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.00234"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:05:39Z","timestamp":1698123939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/lary.29237"],"URL":"https:\/\/doi.org\/10.1002\/lary.29237","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"assertion":[{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}