{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:43Z","timestamp":1786978183218,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"\n Objectives\/Hypothesis<\/jats:title>\n To better understand the significance of pain as a predictor of disease severity in parotid gland malignancy.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n A retrospective chart review of patients treated for primary parotid gland malignancy at our institution between 1991 and 2020 was performed.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patient records were retrospectively reviewed and relevant clinical parameters were collected. Patients were stratified into low stage (I and II) disease and high stage (III and IV) disease groups to analyze the independent effect of pain at initial presentation on disease recurrence rate and disease\u2010free survival using Kaplan\u2013Meier survival curves and an independent two\u2010sample\n t<\/jats:italic>\n \u2010test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 154 patients evaluated, there were 69 patients in the low stage group and 80 patients in the high stage group. Thirty\u2010seven high stage patients presented with pain. High stage patients with pain were significantly more likely to develop disease recurrence than high stage patients without pain (58.5% [22\/37] versus 33.3% [13\/39],\n P<\/jats:italic>\n \u00a0=\u2009.022). High stage patients with pain also had significantly decreased disease\u2010free survival time compared to high stage patients without pain (\n P<\/jats:italic>\n \u00a0=\u2009.027).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Pain on presentation appears to be a poor prognostic factor for patients with parotid gland malignancy. For patients with demonstrated high stage disease, pain is independently associated with increased risk of recurrence and decreased disease\u2010free survival time.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n \n 4\n Laryngoscope<\/jats:italic>\n , 131:1503\u20131508, 2021\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lary.29273","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T14:23:18Z","timestamp":1607782998000},"page":"1503-1508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Significance of Pain in Parotid Gland Malignancy"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-1590","authenticated-orcid":false,"given":"Sophia","family":"Colevas","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery, Department of Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery, Department of Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Glazer","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery, Department of Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Hartig","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery, Department of Surgery University of Wisconsin School of Medicine and Public Health Madison Wisconsin U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.11.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02870.x"},{"key":"e_1_2_6_4_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132016","author":"Howlader N","year":"2019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200308000-00028"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<2057::AID-CNCR24>3.0.CO;2-F"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817751888"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5224-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.12.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890080309"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.08.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870230067009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870150075010"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:38:31Z","timestamp":1693409911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,12]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/lary.29273"],"URL":"https:\/\/doi.org\/10.1002\/lary.29273","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,12]]},"assertion":[{"value":"2020-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}