{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:14:29Z","timestamp":1778814869133,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DC000040"],"award-info":[{"award-number":["5T32DC000040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To apply a novel sialography classification system to identify parotid and submandibular ductal findings following I\u2010131 therapy and to assess correlates to dose and duration of symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective single\u2010center case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent sialography between February 2008 and February 2019 after previously receiving I\u2010131 treatment were identified via a retrospective chart review. Their sialograms were systematically evaluated and scored by applying the Iowa parotid sialogram scale to also include submandibular gland analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 337 sialograms, 30 (five submandibular, 25 parotid) underwent analysis. Ductal stenosis was identified in all sialograms and was graded as moderate (&gt;50%\u201375%) in 7\/30 cases and severe (&gt;75%) in 15\/30 cases. The distal (main) duct was narrowed in 23\/30 cases. No association was identified between degree of ductal stenosis and I\u2010131 dose (<jats:italic>P<\/jats:italic> = .39), age (<jats:italic>P<\/jats:italic> = .81), or time from I\u2010131 therapy to sialogram (<jats:italic>P<\/jats:italic> = .97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Iowa parotid sialogram scale was successfully applied to report abnormalities of the parotid and submandibular ductal system. The most common manifestation of I\u2010131\u2010associated sialadenitis was a severe stenosis within the distal salivary duct. No statistically significant association was found between degree of ductal stenosis and dose of I\u2010131, age, or duration of symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1450\u2013E1456, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29279","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T12:58:56Z","timestamp":1605617936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sialographic Analysis of <scp>Radioiodine\u2010Associated<\/scp> Chronic Sialadenitis"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-407X","authenticated-orcid":false,"given":"Ryan K.","family":"Thorpe","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Iowa Hospitals and Clinics  Iowa City Iowa U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan J.","family":"Foggia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Iowa Hospitals and Clinics  Iowa City Iowa U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4284-5792","authenticated-orcid":false,"given":"Kathryn S.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Iowa Hospitals and Clinics  Iowa City Iowa U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Policeni","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Iowa Hospitals and Clinics  Iowa City Iowa U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan E.","family":"Maley","sequence":"additional","affiliation":[{"name":"Department of 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