{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:30:03Z","timestamp":1777570203557,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>As a cardinal symptom of chronic rhinosinusitis (CRS), hyposmia has been recommended to be assessed as a component of CRS disease control. Herein we determine the significance of hyposmia in CRS in the context of nasal obstruction and drainage symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, cross\u2010sectional<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study of 308 CRS patients (102 CRSwNP, 206 CRSsNP) without prior endoscopic sinus surgery. The burden of nasal obstruction and hyposmia were assessed using the corresponding item scores on the 22\u2010item Sinonasal Outcome Test (SNOT\u201022). Burden of nasal discharge was assessed using the mean of \u201cthick nasal discharge\u201d and \u201cthick post\u2010nasal discharge\u201d SNOT\u201022 item scores. Patients were all asked to rate their CRS symptom control as \u201cnot at all,\u201d \u201ca little,\u201d \u201csomewhat,\u201d \u201cvery,\u201d or \u201ccompletely.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In CRSwNP, only 4.9% had a hyposmia score\u2009&gt;\u20091 with nasal obstruction and drainage scores less than or equal to 1. In CRSsNP, only 1.9% had a hyposmia score\u2009&gt;\u20091 with nasal obstruction and drainage scores less than or equal to 1. On univariate association, CRS symptom control was significantly associated with nasal obstruction, hyposmia, and drainage in both CRSwNP and CRSsNP (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05 in all cases). Using multivariable regression to account for all nasal symptoms, only nasal obstruction and nasal discharge scores (but not hyposmia) were significantly associated with CRS symptom control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyposmia rarely occurs without nasal obstruction or nasal drainage, and may therefore be redundant to assess for CRS disease control. Moreover, hyposmia was not associated with patient\u2010reported CRS symptom control when accounting for the burden of nasal obstruction and drainage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2116\u2013E2120, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29280","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:15:10Z","timestamp":1607645710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Olfactory Dysfunction is not a Determinant Of Patient\u2010Reported Chronic Rhinosinusitis Disease Control"],"prefix":"10.1002","volume":"131","author":[{"given":"Adam C.","family":"McCann","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Trope","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tazheh A.","family":"Kavoosi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene M.","family":"Speth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals\u2010, Nasen\u2010, Ohren\u2010 Krankheiten, Hals\u2010und Gesichtschirurgie Kantonsspital Aarau  Aarau Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Gengler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-3508","authenticated-orcid":false,"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Cincinnati College of Medicine  Cincinnati Ohio U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University 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