{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:41:29Z","timestamp":1786333289317,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Although vidian neurectomy (VN) is associated with decreased lacrimation, its impact on dry eye quality\u2010of\u2010life is not well\u2010defined. Endoscopic endonasal transpterygoid approaches (EETA) may require vidian nerve sacrifice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective cohort trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective trial evaluating VN during EETA on lacrimation by phenol red thread testing and dry eye severity by the five\u2010item Dry Eye Questionnaire (DEQ\u20105) was performed. Preservation of the contralateral vidian nerve allowed comparison between the eye subjected to VN and the control eye postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one subjects were enrolled with no preoperative difference in lacrimation between eyes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.617) and overall mild dry eye severity. Although the control eye had no difference in lacrimation pre\u2010 and postoperatively, decreased tearing was noted in the VN eye at 1\u2009month (20.8\u2009mm vs. 15.8\u2009mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015) and at 3\u2009months (23.2\u2009mm vs. 15.8\u2009mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0051) postoperatively. Overall, no difference was noted in the DEQ\u20105 score for dry eye severity between the pre\u2010 and postoperative measures. However, six patients were noted to have moderate to severe dry eye severity postoperatively and five of these six had decreased lacrimation (&lt;20\u2009mm) preoperatively. Patients with decreased tearing preoperatively demonstrated significantly worse postoperative DEQ\u20105 scores when compared to patients with normal tearing (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0056).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VN during EETA results in decreased tearing but is not associated with increased dry eye severity overall. However, patients with decreased tearing preoperatively are at risk for increased dry eye severity and should be counseled for this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2 <jats:italic>Laryngoscope<\/jats:italic>, 131:1487\u20131491, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29287","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T12:49:12Z","timestamp":1606567752000},"page":"1487-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reduced Tearing With Stable Quality of Life After Vidian Neurectomy: A Prospective Controlled Trial"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-5854","authenticated-orcid":false,"given":"Eric W.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Tonya","family":"Stefko","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Fernandez\u2010Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-4522","authenticated-orcid":false,"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116008008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4141"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000216"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.831478"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2014.28.4029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.284"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1482-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.4.212"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.72"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00958-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22326"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22327"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-016-2274-y"},{"key":"e_1_2_6_15_1","first-page":"332","article-title":"Limits of endoscopic endonasal transpterygoid approach to cavernous sinus and Meckel's cave","volume":"62","author":"Hardesty DA","year":"2018","journal-title":"J Neurosurg Sci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.81979"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2009.12.010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3704"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21462"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27895"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21991"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:38:11Z","timestamp":1693424291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,28]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/lary.29287"],"URL":"https:\/\/doi.org\/10.1002\/lary.29287","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,28]]},"assertion":[{"value":"2020-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}