{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:16:14Z","timestamp":1772450174384,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the voice and speech outcomes after tubed supraglottic laryngeal closure (TSLC) surgery to treat chronic aspiration after radiotherapy for head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A retrospective case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of patients who underwent radiotherapy for head and neck cancer and who later required total laryngectomy or TSLC for chronic aspiration between 2004 and 2017 were retrieved from a dysphagia clinic. Preoperative and postoperative voice and speech were assessed by the GRBAS and INFVo rating scales. Control subjects who underwent radiotherapy alone or total laryngectomy with a tracheoesophageal prosthesis for other indications were recruited for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 15 patients who underwent a TSLC with a mean age of 57.3\u2009years (45\u201375\u2009years), 13 were male and 2 female. All patients had a history of nasopharyngeal carcinoma. The success rate of speech production using their own larynx following an intact TSLC was 64%. There was no statistically significant difference in voice and speech ratings between preoperative and TSLC subjects on the GRBAS (<jats:italic>P<\/jats:italic> = .32) and INFVo scales (<jats:italic>P<\/jats:italic> = .57), although the quality of voice appeared to deteriorate after TSLC. However, the INFVo scale for impression, intelligibility and unsteadiness of the voice after TSLC was statistically significantly better than for laryngectomy with tracheoesophageal speech.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A tubed supraglottic laryngeal closure controls chronic aspiration while preserving the larynx for phonation, and results in a better voice and speech quality than a laryngectomy with a voice prosthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1616\u2013E1623, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29298","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T22:51:28Z","timestamp":1606949488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perceptual Voice and Speech Analysis after Supraglottic Laryngeal Closure for Chronic Aspiration in Head and Neck Cancer"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2669-9126","authenticated-orcid":false,"given":"Peter K. M.","family":"Ku","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander C.","family":"Vlantis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenon W. C.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osan Y. M.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-282X","authenticated-orcid":false,"given":"Ryan H. W.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex K. F.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S. C.","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin P. L.","family":"So","sequence":"additional","affiliation":[{"name":"Department of Speech Therapy Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-580X","authenticated-orcid":false,"given":"Thomas K. T.","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery United Christian Hospital, Tseung Kwan O Hospital  Tseung Kwan O Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"van Hasselt","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-5223","authenticated-orcid":false,"given":"Michael C. F.","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The Chinese University of Hong Kong, Prince of Wales Hospital  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(82)80046-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100101641"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)31500-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2725-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198012000-00002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700506"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199501000-00018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197501000-00012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700507"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198410000-00007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197203000-00011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1983.00800160003001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109990351"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29298"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0960-z"},{"key":"e_1_2_6_17_1","first-page":"81","volume-title":"Clinical Examination of Voice","author":"Hirano M","year":"1981"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109005398"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0995-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27171"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.12.006"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.180814"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-1033-z"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097401"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2015.01.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2003.44.4.615"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28343"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28517"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46223-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.06.024"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880300062009"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10265"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9128-x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.06.011"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5055-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.05.060"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.05.022"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:29:14Z","timestamp":1693618154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,2]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/lary.29298"],"URL":"https:\/\/doi.org\/10.1002\/lary.29298","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,2]]},"assertion":[{"value":"2020-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}