{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:29:10Z","timestamp":1770647350427,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the role of autofluorescence (AF) monitoring with near\u2010infrared fluorescence imaging (NIFI) in identifying parathyroid lesions in primary or secondary hyperparathyroidism (P\u2010HPT or S\u2010HPT) surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve lesions each were resected from 12 and 3 patients with P\u2010HPT and S\u2010HPT, respectively. The mean and maximum AF intensities of the lesions normalized to that of the thyroid tissue for in situ and ex vivo preparations were compared between P\u2010HPT and S\u2010HPT. Subjective visual classifications of AF intensity were compared with postoperative quantitative assessments. The unevenness of AF distribution inside the lesions was assessed by determining the ratio of maximum to mean AF intensity and comparing them with the corresponding ratio for normal parathyroid glands (PGs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all quantitative comparisons (in situ\/ex vivo, mean, and maximum AF), AF intensities of P\u2010HPT were stronger than those of S\u2010PHT. The AF\u2010positive rate in in situ subjective visual classification was higher for P\u2010HPT (100% vs. 33%). Subjective visual classifications showed a positive correlation with AF intensities. The ratio of maximum to mean AF was higher in P\u2010HPT and S\u2010HPT than in normal PGs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For P\u2010HPT, AF intensity in both in situ and ex vivo preparations was sufficiently high and correlated with the subjective visual classification, suggesting that NIFI may be useful for confirming P\u2010HPT lesions. In contrast, NIFI may have only a minor role in S\u2010HPT surgeries owing to the weak\u2010AF of S\u2010HPT lesions. HPT lesions show an uneven AF intensity distribution compared with normal PGs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:E2097\u2013E2104, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29310","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T13:35:07Z","timestamp":1607693707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of Autofluorescence With Near\u2010Infrared Fluorescence Imaging Between Primary and Secondary Hyperparathyroidism"],"prefix":"10.1002","volume":"131","author":[{"given":"Mika","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Shodo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arata","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Niigata University Graduate School of Medical and Dental Sciences  Niigata 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role of the calcium\u2010sensing receptor in the pathophysiology of secondary hyperparathyroidism","volume":"1","author":"Riccardi D","year":"2008","journal-title":"NDT Plus"}],"container-title":["The 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