{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:30:53Z","timestamp":1747150253563,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Somatostatin receptors (SSTRs) are highly expressed in neuroendocrine tumors and is exploited for its imaging and treatment. SSTRs expression is also demonstrated in diverse benign and malignant tumor cell types and proliferating peri\u2010tumoral vessels. Similarly, Juvenile Nasopharyngeal Angiofibroma (JNA) expresses different SSTRs and may be utilized for its imaging and treatment using DOTA, 1\u2010Nal3\u2010octreotide (DOTANOC)\u2010PET\/CT scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen clinico\u2010radiologically diagnosed primary JNA patients underwent a <jats:sup>68<\/jats:sup>Ga\u2010DOTANOC PET\u2010CT scan. Using a dedicated PET\/CT scanner, a low\u2010dose head and neck spot CT scan was performed after 45 to 60\u2009minutes of intravenous injection of 2 to 3\u2009mCi(74\u2013111\u2009MBq) of DOTANOC. The primary objective was to assess the intensity and pattern of DOTANOC uptake in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DOTANOC expression was noted in all cases (n\u00a0=\u00a019) of primary JNA (100%). The mean (SD) DOTANOC SUVmax ratio of tumor and background was 6.9+\/\u22121.4(range, 3.8\u20139.5). Intra\u2010cranial extension in all 13\/19 patients was prominently visualized due to the absence of DOTANOC uptake in the brain. Compared to the background all stages of JNA showed significant DOTANOC uptake (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). No difference in uptake between advanced\u2010stage tumors and early tumors was noted (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.47). A statistically non\u2010significant negative trend was noted for decreasing uptake with increasing age (Spearman correlation coefficient, r\u00a0=\u00a0\u22120.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This first study of <jats:sup>68<\/jats:sup>Ga\u2010DOTANOC\u2010PET\/CT scan in JNA demonstrates consistent and reliable uptake activity in all patients irrespective of age and stage. This opens up possibilities to physiological diagnostic imaging with a promise of greater specificity and sensitivity and may have applications in ambivalent diagnostic situations such as the detection of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:1509\u20131515, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29332","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T14:39:18Z","timestamp":1608820758000},"page":"1509-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp><sup>68<\/sup>Ga DOTANOC PET<\/scp>\/<scp>CT<\/scp> Scan in Primary Juvenile Nasopharyngeal Angiofibroma \u2010 A Pilot Study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6941-9892","authenticated-orcid":false,"given":"Pirabu","family":"Sakthivel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreedharan Thankarajan","family":"Arunraj","sequence":"additional","affiliation":[{"name":"Department of Nuclear medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashu Seith","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Radiology All India Institute of Medical 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