{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:56:10Z","timestamp":1776185770262,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This is an ancillary study of a multi\u2010institutional randomized non\u2010inferiority phase III trial of accelerated fractionation (AF) versus standard fractionation (SF) radiation therapy for T1\u20102N0M0 glottic cancer (JCOG0701). Biopsy specimens of tumors from the patients enrolled in the JCOG0701 are collected and the association between clinical outcomes and histopathologic features such as expression of epithelial cell adhesion molecule (EpCAM), p53, and p16 were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five slices of undyed slides from biopsy specimens were sent to the National Cancer Center Hospital and all the specimens were assessed for the expression of EpCAM, p53, and p16. The primary objective was to investigate the association between 3\u2010year progression\u2010free survival (PFS) and expression of EpCAM, p53, and p16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 88 out of 370 patients were enrolled in this ancillary study. The 3\u2010year PFS for tumors with strong expression of EpCAM was 70.6% (95% CI 43.1%\u201386.6%), while that of tumors without strong expression of EpCAM was 77.5% (95% CI 65.9%\u201385.5%) with no remarkable difference between groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.67). Likewise, there was no significant difference in 3\u2010year PFS between tumors regardless of p53 or p16 status. However, in a subgroup analysis for 17 patients with a strong expression of EpCAM, AF showed better 3\u2010year PFS than SF (100% vs 54.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>From the current study, it could not be concluded that EpCAM, p16, and p53 were prognostic factors for early\u2010stage glottic cancer after primary radiation therapy. AF might be an appropriate fractionation for tumors with a strong expression of EpCAM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3 <jats:italic>Laryngoscope<\/jats:italic>, 131:1522\u20131527, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29348","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T21:06:51Z","timestamp":1609189611000},"page":"1522-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Value of Epithelial Cell Adhesion Molecules in <scp>T1\u20102N0M0<\/scp> Glottic Cancer"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-9987","authenticated-orcid":false,"given":"Naoya","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-7883","authenticated-orcid":false,"given":"Taisuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryunosuke","family":"Machida","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kodaira","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology Showa University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Shikama","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Medicine, Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Niigata Cancer Center Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Graduate School of Biomedical Health Sciences, Hiroshima University  Hiroshima 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