{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:28:25Z","timestamp":1747391305107,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>We investigated growth patterns and pathological features in intermediate\u2010size laryngeal carcinoma amenable to supraglottic laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed patients who underwent an open partial horizontal laryngectomy (OPHL) type I. We analyzed pathological data, tumor sizes, overall survival, disease\u2010specific survival, local control, and laryngeal preservation. Results were stratified between three groups: group I comprised patients with endolaryngeal carcinoma, group II comprised patients with anterior epilaryngeal carcinoma who underwent an OPHL type I\u2009+\u2009base of tongue (BOT), group III comprised patients with lateral epilaryngeal carcinoma who underwent an OPHL type I\u2009+\u2009pyriform sinus (PIR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight patients were analyzed. The 5\u2010year rates of overall survival, disease\u2010specific survival, local control, and laryngeal preservation were 68.4%, 83.7%, 91.6%, and 98.3%, respectively. The tumor sizes at pathological examination were similar between the three groups (mean 27\u2009mm, <jats:italic>P<\/jats:italic> = .80) and were associated with pathological features, notably pre\u2010epiglottic space (PES) invasion (24.9\u2009mm vs. 32.2\u2009mm, <jats:italic>P<\/jats:italic> = .01), occult invaded lymph nodes (22.6\u2009mm vs. 29.9\u2009mm, <jats:italic>P<\/jats:italic> = .03), and trends for margins status (26.5\u2009mm vs. 29.3\u2009mm, <jats:italic>P<\/jats:italic> = .45). The risks of PES invasion, occult lymph nodes, and positive margins, respectively, predominated in group I (41.7%), group II (56.3%), and group III (23.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In intermediate\u2010size tumors amenable to supraglottic laryngectomy, pathological features are associated with tumor size according to group stratification based on tumor location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:E1980\u2013E1986, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29367","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T05:11:18Z","timestamp":1609909878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Features in Intermediate\u2010Size Supraglottic Tumors Treated With Open Supraglottic Laryngectomy"],"prefix":"10.1002","volume":"131","author":[{"given":"Marialessia","family":"Damiani","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mercante","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center \u2013 IRCCS  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Abdellaoui","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Guerlain","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Moya\u2010Plana","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Temam","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yungan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-4964","authenticated-orcid":false,"given":"Philippe","family":"Gorphe","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Institute University Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_6_3_1","unstructured":"Surveillance E and End Results (SEER) Cancer Statistics Review (CSR) 1975\u20132017 U. S. National Institute of Health National Cancer Institute. Relative Survival by Year of Diagnosis Both Sexes.https:\/\/seer.cancer.gov\/csr\/1975_2017\/results_single\/sect_12_table.10.pdf. Accessed December 1 2020."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20778"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24163"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104848"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215119000707"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12101"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3056-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-864"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1028-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00121"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3024-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00408"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2018.1490031"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5027-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-018-0321-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200104"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199008000-00007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0824-y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21288"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1198"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24408"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26961"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198004000-00005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.1095"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:05:08Z","timestamp":1698123908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/lary.29367"],"URL":"https:\/\/doi.org\/10.1002\/lary.29367","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"type":"print","value":"0023-852X"},{"type":"electronic","value":"1531-4995"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"2020-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}