{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:52:41Z","timestamp":1776095561073,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>A variety of laryngeal pathologies are increasingly being managed with in\u2010office KTP laser (IOKTP) endoscopic procedures. The primary goal of this study was to identify patient characteristics and disease\u2010related features that correlated with tolerance for IOKTP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a retrospective review of adult patients undergoing office\u2010based laryngeal laser procedures between November 2016 and December 2019 at a tertiary care center. Two blinded otolaryngologist reviewers scored videotaped recordings of IOKTP procedures and assessed severity and distribution of disease using a modified Derkay score, and evaluated procedure tolerance using a visual analog scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 56 patients who received IOKTP procedures for laryngeal pathology were reviewed, 42 male and 14 female, with a mean age of 61\u2009years. Gender, age, and BMI were not correlated with tolerance. There was a moderate, negative correlation between tolerance and total number of pathological anatomic laryngeal subsites (rs(56)\u00a0=\u00a0\u22120.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). There was a weak, negative correlation between tolerance and total modified Derkay score (rs(56)\u00a0=\u00a0\u22120.29, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). The median tolerance score was lower for patients with posterior lesions (Mdn\u00a0=\u00a06.4) compared with patients with non\u2010posterior lesions (Mdn\u00a0=\u00a07.4), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04, and lower for current or former smokers (Mdn\u00a0=\u00a06.5) compared with never smokers (Mdn\u00a0=\u00a07.3), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with large disease burden or posterior lesions and patients with smoking history may exhibit poorer tolerance of IOKTP procedures, factors which can help guide pre\u2010procedural counseling and management decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>IV <jats:italic>Laryngoscope<\/jats:italic>, 131:E2292\u2013E2297, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29370","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T04:21:45Z","timestamp":1610079705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Factors Associated With Tolerance for <scp>In\u2010Office<\/scp> Laryngeal Laser Procedures"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2505-5326","authenticated-orcid":false,"given":"Melissa","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Southern California  Los Angeles California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Arora","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California 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