{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:17:33Z","timestamp":1774883853311,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>Early and objective prediction of complications in head and neck reconstructive surgery could decrease morbidity and prolonged hospital stays but unfortunately most complications are not identified until their effect is fully realized. There are limited data regarding the association of platelet levels and post\u2010operative complications. Post\u2010operative thrombocytosis (POTCT) is proposed as a possible indicator for complications following free\u2010flap reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multisite retrospective chart review of patients undergoing free tissue transfer between 2013 and 2018 was undertaken. POTCT was recorded and data normalized between institutions. Data were compared between groups using <jats:italic>t<\/jats:italic>\u2010tests and logistic regression (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). A lag\u20101 difference was used to compare the rate of change in platelet values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 398 patients were included. POTCT and a rate of change of 30\u2009K between POD5 and POD6 was significantly associated with the presence of post\u2010operative complication (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). Additionally, lag\u20101 difference demonstrated a significant association of change in daily platelet counts and complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Isolated POTCT may be an early predictor of complications in HNC patients undergoing free\u2010flap reconstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:1542\u20131547, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29386","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T19:24:26Z","timestamp":1610738666000},"page":"1542-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Thrombocytosis Predicts Surgical Site Infection in Head and Neck Microvascular <scp>Surgery\u2010 A<\/scp> Pilot Study"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-9907","authenticated-orcid":false,"given":"Brianna N.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of California, Davis  Sacramento California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-6951","authenticated-orcid":false,"given":"Rusha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology West Virginia University  Morgantown West Virginia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kejner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Kentucky  Lexington Kentucky U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology West Virginia University  Morgantown West Virginia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jad","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Statistics West Virginia University  Morgantown West Virginia U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Bewley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of California, Davis  Sacramento California U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25038"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3498-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26039"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5035-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817742373"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.01.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590500498166"},{"key":"e_1_2_6_9_1","first-page":"415","article-title":"Etiology of thrombocytosis in a general medicine population: analysis of 801 cases with emphasis on infectious causes","volume":"4","author":"Rose SR","year":"2012","journal-title":"J Clin Med 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