{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:47:47Z","timestamp":1787755667972,"version":"build-2784847793"},"reference-count":75,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>The purpose of this review is to summarize evidence\u2010based data regarding the ototoxic effects of potential COVID\u201019 therapeutics to treat patients suffering from SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medications under investigation as novel therapeutics to treat COVID\u201019 were identified using the search term <jats:italic>coronavirus therapeutics<\/jats:italic>, <jats:italic>COVID therapeutics<\/jats:italic>, and <jats:italic>SARS\u2010CoV\u20102 therapeutics<\/jats:italic> on <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> and the PubMed Database. A literature review was performed using the PubMed Database for each proposed COVID\u201019 therapeutic to identify relevant articles. Search criteria included Medical Subject Headings (MeSH) and key word search terms for <jats:italic>ototoxicity<\/jats:italic>, <jats:italic>vestibulotoxicity<\/jats:italic>, <jats:italic>hearing disorders<\/jats:italic>, and <jats:italic>vertigo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six proposed COVID\u201019 therapeutics were identified as possessing ototoxic side effects including chloroquine and hydroxychloroquine, azithromycin, lopinavir\u2010ritonavir, interferon, ribavirin, and ivermectin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Available evidence suggests that ototoxic effects may be improved or mitigated by stopping the offending agent. Recognition of hearing loss, tinnitus, or imbalance\/vertigo is therefore crucial to facilitate early intervention and prevent long\u2010term damage. Hospitals should consider the inclusion of audiologic monitoring protocols for patients receiving COVID\u201019 therapeutics with known ototoxicity, especially in high\u2010risk patient groups such as the elderly and hearing impaired. <jats:italic>Laryngoscope<\/jats:italic>, 131:1626\u20131632, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29424","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T06:01:06Z","timestamp":1611554466000},"page":"1626-1632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Narrative Review of Pharmacologic Treatments for <scp>COVID<\/scp>\u201019: Safety Considerations and Ototoxicity"],"prefix":"10.1002","volume":"131","author":[{"given":"Christine","family":"Little","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York 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