{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:36:16Z","timestamp":1781865376982,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective\/Hypothesis<\/jats:title><jats:p>To investigate the endovascular intervention or extracranial\/intracranial (EC\/IC) vascular bypass in the management of patients with head and neck cancer\u2010related carotid blowout syndrome (CBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of clinical data of patients with head and neck cancer\u2010related CBS treated by endovascular intervention and\/or EC\/IC vascular bypass, analysis of its bleeding control, neurological complications, and survival results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thrity\u2010seven patients were included. Twenty\u2010five were associated with external carotid artery (ECA); twelve were associated with internal or common carotid artery (ICA\/CCA). All patients with ECA hemorrhage were treated with endovascular embolization. Of the 12 patients with ICA\/CCA hemorrhage, 9 underwent EC\/IC bypass, 1 underwent endovascular embolization, and 3 underwent endovascular stenting. For patients with ECA\u2010related CBS, the median survival was 6\u2009months, and the 90\u2010day, 1\u2010year, and 2\u2010year survival rates were 67.1%, 44.7%, and 33.6%, respectively; the estimated rebleeding risk at 1\u2010month, 6\u2010month, and 2\u2010year was 7.1%, 20.0%, and 31.6%, respectively. For patients with ICA\/CCA\u2010related CBS, the median survival was 22.5\u2009months, and the 90\u2010day, 1\u2010year, and 2\u2010year survival rates were 92.3%, 71.8%, and 41.0%, respectively; the estimated rebleeding risk at 1\u2009month, 6\u2009months, and 2\u2009years is 7.7%,15.4%, and 15.4%, respectively. ICA\/CCA\u2010related CBS patients have significantly longer survival time and lower risk of rebleeding, which may be related to the more use of EC\/IC vascular bypass as a definite treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with ICA\/CCA\u2010related CBS, if there is more stable hemodynamics, longer expected survival, EC\/IC vascular bypass is preferred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 131:1548\u20131556, 2021<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.29427","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T04:14:21Z","timestamp":1613276061000},"page":"1548-1556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Extracranial\/Intracranial Vascular Bypass in the Treatment of Head and Neck Cancer \u2010 Related Carotid Blowout Syndrome"],"prefix":"10.1002","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-4276","authenticated-orcid":false,"given":"Ping\u2010An","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, Head and Neck Surgery The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-5821","authenticated-orcid":false,"given":"Raymond King\u2010Yin","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, Head and Neck Surgery The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy Yu\u2010Wai","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology, Head and Neck Surgery The University of Hong Kong\u2010Shenzhen Hospital  Shenzhen P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23590"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.04.056"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200404000-00010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnis.2009.001131"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26144"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000738"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24234"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2009.080240"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24721"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139821"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.12.047"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S180164"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.04.058"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20150136"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971189"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2379"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0589"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.11.024"},{"key":"e_1_2_6_21_1","first-page":"c561\u2013569","article-title":"Evaluation of the outcomes of endovascular management for patients with head and neck cancers and associated carotid blowout syndrome of the external carotid artery","volume":"36","author":"Chang F","year":"2013","journal-title":"Clin Radiol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.08.024"}],"updated-by":[{"DOI":"10.1002\/lary.30624","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000}}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.29427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.29427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:37:24Z","timestamp":1693424244000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.29427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/lary.29427"],"URL":"https:\/\/doi.org\/10.1002\/lary.29427","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/lary.30624","asserted-by":"object"}]},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"assertion":[{"value":"2020-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}